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A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
JoVE Journal
Medicine
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JoVE Journal Medicine
A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
DOI:

07:56 min

February 17, 2023

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Chapters

  • 00:04Introduction
  • 00:53Preparing the Langendorff Apparatus
  • 02:01Preparing the Hardware and Software
  • 02:53Preparing the Isolated Heart
  • 04:20Perfusing and Electrically Stimulating the Heart
  • 05:34Results: Success Rate of Long‐Term Ventricular Fibrillation
  • 07:32Conclusion

Summary

Automatic Translation

This protocol presents a model of long-term ventricular fibrillation in rat hearts induced by continuous stimulation with low-voltage alternating current. This model has a high success rate, is stable, reliable, and reproducible, has a low impact on cardiac function, and causes only mild myocardial injury.

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