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Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
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Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

DOI:
10.3791/50983-v

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10:18 min

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June 29, 2014

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, , , ,
1Cardio Vascular Disease Biology,Rajiv Gandhi Centre for Biotechnology, 2Animal Research Facility,Rajiv Gandhi Centre for Biotechnology, 3Cardiology Department,Sree Chitra Tirunal Institute for Medical Sciences & Technology

Chapters

  • 00:00Title
  • 00:06Introduction
  • 02:30Pre-Operative Care and Anesthesia
  • 02:43Preparation of the Surgical Site
  • 03:22Tracheal Intubation in Rat
  • 04:05Constriction of Ascending Aorta
  • 07:05Post-operative Care
  • 07:58Confirmation of Successful Constriction of Ascending Aorta
  • 08:14Representative Results
  • 09:21Conclusion

Summary

Automatic Translation

Automatic Translation

We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.

Tags

Ascending Aortic ConstrictionPressure OverloadCardiac HypertrophyHeart FailureSurgical ModelRatsTrachea IntubationAorta ConstrictionDoppler-echocardiographyCardiac RemodelingContractile Properties

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