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Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
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Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

DOI:
10.3791/55599-v

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09:24 min

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April 17, 2017

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, , ,
1Neuroscience Graduate Program,University of Cincinnati, 2Department of Biological Sciences,Wright State University, 3Division of Neurosurgery,Cincinnati Children’s Hospital Medical Center

Chapters

  • 00:05Title
  • 00:48Preparation for Surgery
  • 02:24Implanting the Telemetry Device to Record Scalene and Trapezius EMG Activity
  • 07:01Acquiring Simultaneous Electromyography and Plethysmography Signals
  • 08:00Results: Representative Whole-body Plethysmography (WBP) and Electromyography Traces
  • 08:56Conclusion

Summary

Automatic Translation

Automatic Translation

This paper introduces a method for repeated measurements of ventilation and respiratory muscle activity in a freely behaving amyotrophic lateral sclerosis (ALS) mouse model throughout disease progression with whole-body plethysmography and electromyography via an implanted telemetry device.

Tags

Respiratory Muscle ActivityVentilationMouse ModelsNeuromuscular DiseaseTelemetry DeviceElectromyographyDiaphragm FunctionALSSpinal Cord InjuryEMG ElectrodesAnesthesiaSurgical ImplantationRespiratory MusclesAccessory Respiratory Muscles

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