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JoVE Journal Developmental Biology
Snabb upptäckt av neurologiska fenotyper i mänskliga neurala prekursorceller (NPC)
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Snabb upptäckt av neurologiska fenotyper i mänskliga neurala prekursorceller (NPC)

Article DOI: 10.3791/56628-v • 10:47 min • March 2nd, 2018
March 2nd, 2018 •
*1, *1, 1, 2, 3, 3, 4, 5, 2, 1
1Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 2Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 3The Child Health Institute of NJ, Department of Obstetrics, Gynecology, and Reproductive Services, Rutgers Robert Wood Johnson Medical School, 4The Child Health Institute of NJ, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 5Department of Genetics, Rutgers University
* These authors contributed equally

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Neurologiska processer som spridning, migration och neurite utväxt är ofta oroade i neuropsykiatriska sjukdomar. Således presenterar vi protokoll för att snabbt och reproducibly bedöma dessa neurologiska processer i mänskliga iPSC-derived NPCs. Dessa protokoll också att bedömningen av effekterna av relevanta tillväxtfaktorer och therapeutics på NPC utveckling.

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Utvecklingsbiologi fråga 133 neuroutvecklingssjukdomar utvecklingsbiologi neurala prekursorceller iPSC hjärnsjukdom autism tillväxtfaktorer spridning neurite utväxt cellmigration
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