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Journal / Genetics / Exosomes de lavagem broncoalveolar em lesão…
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JoVE Journal Genetics
Exosomes de lavagem broncoalveolar em lesão pulmonar séptico induzidas pelo lipopolissacarídeo
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Exosomes de lavagem broncoalveolar em lesão pulmonar séptico induzidas pelo lipopolissacarídeo

Article DOI: 10.3791/57737-v • 08:27 min • May 21st, 2018
May 21st, 2018 •
1,2, 1, 1,2
1Department of Veterans Affairs, Atlanta VAMC, 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Emory University

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Os ratos expostos ao LPS intraperitoneal secretam exosomes no líquido de lavagem (BAL) bronco-alveolar que são embalados com miRNAs. Usando um sistema de co-cultura, mostramos que exosomes lançados no fluido BAL perturbará a expressão de proteínas de junção apertada nas células epiteliais brônquicas e aumentar a expressão de citocinas pró-inflamatórias que acentuam a lesão pulmonar.

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Genética edição 135 Exosomes microRNAs miR-155 miR-146 LPS pulmonar sepse
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