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Journal / Genetics / 支气管肺泡灌洗外来体在脂多糖致脓毒性肺损伤中的作用…
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Genetics

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JoVE Journal Genetics
支气管肺泡灌洗外来体在脂多糖致脓毒性肺损伤中的作用
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支气管肺泡灌洗外来体在脂多糖致脓毒性肺损伤中的作用

Article DOI: 10.3791/57737-v • 08:27 min • May 21st, 2018
May 21st, 2018 •
1,2, 1, 1,2
1Department of Veterans Affairs, Atlanta VAMC, 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Emory University

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暴露于腹腔内的 LPS 分泌外来体的小鼠支气管肺泡灌洗 (球) 液, 包装与 miRNAs。使用共培养系统, 我们表明, 外来体释放的球液扰乱支气管上皮细胞紧密连接蛋白的表达, 并增加支持炎症细胞因子的表达, 加重肺损伤。

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遗传学 问题 135 外来体 microRNAs miR-155 miR-146a LPS 肺 脓毒症
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