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The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
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JoVE Journal Behavior
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

DOI:
10.3791/58184-v

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07:13 min

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October 24, 2018

•

,
1School of Behavioral Science,The Academic College Tel-Aviv-Yaffo, 2Department of Education and Psychology,Open University

Chapters

  • 00:00Title
  • 00:44Unpredictable Chronic Mild Stress (UCMS) Protocol
  • 04:03Treatment Phase and Sucrose Preference Test
  • 05:22Results: UCMS Protocol Effectively Induces Anhedonia
  • 06:48Conclusion

Summary

Automatic Translation

Automatic Translation

Here we present the unpredictable chronic mild stress protocol in mice. This protocol induces a long-term depressive-like phenotype and enables to assess the efficacy of putative antidepressants in reversing the behavioral and neuromolecular depressive-like deficits.

Tags

UCMS ProtocolChronic Mild StressAnhedoniaDepressionAnxietyPharmacological TreatmentsMouse Model

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