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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

DOI:
10.3791/58269-v

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07:26 min

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November 20, 2018

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, , ,
1Nanobiotechnology, Molecular Imaging and Metabolomics Lab,Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 2CIC biomaGUNE and CIBER de Enfermedades Respiratorias (CIBERES). Ikerbasque, Basque Foundation for Science,Universidad Complutense de Madrid (UCM), 3Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC),CIBER de Enfermedades Respiratorias (CIBERES)

Chapters

  • 00:04Title
  • 00:26Synthesis of Citrate-Coated Iron Oxide Nanoparticles
  • 01:41Synthesis of 68Ga Core-Doped Iron Oxide Nanoparticles (68Ga-C-IONP)
  • 03:19Analysis of 68Ga Core-Doped Iron Oxide Nanoparticles (68Ga-C-IONP)
  • 04:42Results: Characterization of 68Ga Core-Doped Iron Oxide Nanoparticles
  • 06:40Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we present a protocol to obtain 68Ga core-doped iron oxide nanoparticles via fast microwave-driven synthesis. The methodology renders PET/(T1)MRI nanoparticles with radiolabeling efficiencies higher than 90% and radiochemical purity of 99% in a 20-min synthesis.

Tags

Keyword Extraction:68GaCore-dopedIron Oxide NanoparticlesDual PET/MR ImagingMicrowave SynthesisReproducibleIron Chloride HexahydrateCitric Acid Trisodium Salt DihydrateHydrazine HydrateGel Filtration Desalting ColumnGallium-68 GeneratorGallium-68 ChlorideHydrodynamic Size

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