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Journal / Biochemistry / Humanperifert blod nøytrofil isolasjon for å…
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Biochemistry
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JoVE Journal Biochemistry
Humanperifert blod nøytrofil isolasjon for å forhøre Parkinsons tilknyttede LRRK2 Kinase Pathway ved å vurdere Rab10 fosforylering
Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy (NMR) and Microscale Thermophoresis (MST)
Journal (Biochemistry)
Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy (NMR) and Microscale Thermophoresis (MST)
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Journal (Biochemistry)
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Humanperifert blod nøytrofil isolasjon for å forhøre Parkinsons tilknyttede LRRK2 Kinase Pathway ved å vurdere Rab10 fosforylering

Article DOI: 10.3791/58956-v • 12:49 min • March 21st, 2020
March 21st, 2020 •
*1, *1, 2, 2, 2, 3, 4, 5, 1, 1,6
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, 2The Michael J. Fox Foundation for Parkinson's Research, 3Department of Medical and Molecular Genetics, Indiana University School of Medicine, 4Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, 5Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, 6Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee
* These authors contributed equally

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Mutasjoner i leucine rike gjenta kinase 2 genet (LRRK2) forårsake arvelig Parkinsons sykdom. Vi har utviklet en enkel og robust metode for å vurdere LRRK2-kontrollert fosforylering av Rab10 i humane perifere blodnøytrofiler. Dette kan bidra til å identifisere personer med økt LRRK2 kinase pathway aktivitet.

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Biokjemi Utgave 157 Parkinsons sykdom biomarkører LRRK2 kinase perifere blod nøytrofiler Rab proteiner vesikkel handel protein fosforylering
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