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人类外周血神经细胞分离通过评估Rab10磷酸化来询问帕金森氏症相关的LRRK2激酶途径
JoVE Journal
Biochemistry
Author Produced
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JoVE Journal Biochemistry
Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
DOI:

12:49 min

March 21, 2020

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Chapters

  • 00:01Introduction
  • 00:48Neutrophil Isolation from Human Peripheral Blood
  • 07:18LRRK2 Kinase Inhibitor Treatment
  • 10:33Results
  • 12:14Conclusion

Summary

Automatic Translation

白氨酸丰富的重复激酶2基因(LRRK2)的突变导致遗传性帕金森病。我们开发了一种简单可靠的方法,用于评估人类外周血中Rab10的LRRK2控制磷酸化。这可能有助于识别具有增加LRRK2激酶通路活性的个人。

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