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Journal / Neuroscience / 将γ-氨基丁酸 (GABA) 电泳到癫痫焦点中进行,…
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Neuroscience

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JoVE Journal Neuroscience
将γ-氨基丁酸 (GABA) 电泳到癫痫焦点中进行, 防止小鼠癫痫发作
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将γ-氨基丁酸 (GABA) 电泳到癫痫焦点中进行, 防止小鼠癫痫发作

Article DOI: 10.3791/59268-v • 07:01 min • May 16th, 2019
May 16th, 2019 •
*1,5, *2,3, 1,4, 2,3, 1,5
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division, University of Cambridge, 3Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged
* These authors contributed equally

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癫痫研究的挑战是在经典治疗不足的情况下, 为患者开发新的治疗方法。使用一个新的协议--在植入药物输送系统的帮助下--我们能够通过将 GABA 的电泳传递到癫痫的焦点来控制麻醉小鼠的癫痫发作。

Tags

神经科学 第147期 微流体离子泵 μFIP 电泳 癫痫 癫痫 癫痫发作 癫痫焦点 GABA 海马 硅探针 4-氨基吡啶 4AP 小鼠
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