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啮齿动物的中枢神经系统药物直接脑室交货
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal
Neuroscience
Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
Please note that all translations are automatically generated.
Click here for the English version.
啮齿动物的中枢神经系统药物直接脑室交货
DOI:
10.3791/50326-v
•
14:55 min
•
May 12, 2013
•
Sarah L. DeVos
,
Timothy M. Miller
1
Department of Neurology
,
Washington University in St. Louis School of Medicine
Chapters
00:05
Title
01:54
Pre-Surgical Procedure
03:49
Implantation of Alzet Osmotic Pump
08:01
Changing or Removing Alzet Osmotic Pump
09:51
Administration of an Intracerebroventricular Bolus
12:12
Results: Intraventricular Delivery of Antisense Oligonucleotides to the Rodent Central Nervous System
14:36
Conclusion
Summary
Automatic Translation
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Automatic Translation
我们描述了一种方法,目标通过植入导管或进行大剂量注射到在小鼠右侧脑室中枢神经系统的药物。我们特别专注于交付反义寡核苷酸。这种技术是很容易适应其他药物和大鼠。
Tags
Direct Intraventricular Delivery
Central Nervous System
CNS
Rodent
Antisense Oligonucleotides
ASOs
Gene Knockdown
Splicing
Alzet Osmotic Pumps
Lateral Ventricle
Bolus Injection
Cerebral Ventricular System
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