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Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
JoVE Journal
Medicine
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JoVE Journal Medicine
Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
DOI:

00:08 min

August 24, 2019

, , , , , , , ,

Chapters

  • 00:04Title
  • 00:33Mouse Position Preparation
  • 01:09Thorax Entry
  • 02:24Aortic Exposure
  • 03:04Elastase Exposure
  • 03:48Chest Closure and Recovery
  • 04:28Thoracic Aortic Aneurysm (TAA) Harvest
  • 06:58Results: Representative Effects of TAA Formation
  • 07:54Conclusion

Summary

Automatic Translation

We describe a surgical protocol to consistently induce robust descending thoracic aortic aneurysms in mice. The procedure involves left thoracotomy, thoracic aorta exposure, and placement of a sponge soaked in porcine pancreatic elastase on the aortic wall.

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