Pedro R. Lowenstein Department of Neurosurgery University of Michigan Medical School Biography Publications Institution JoVE Articles Pedro R. Lowenstein has not added a biography. If you are Pedro R. Lowenstein and would like to personalize this page please email our Author Liaison for assistance. Publications Glioma Trials and Viral Tribulations: Can Anything Be Concluded from Non-controlled Trials? Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2015 | Pubmed ID: 25280917 Blockade of MTOR Signaling Via Rapamycin Combined with Immunotherapy Augments Antiglioma Cytotoxic and Memory T-cell Functions Molecular Cancer Therapeutics. Dec, 2014 | Pubmed ID: 25256739 Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-independent Vascularization, and Resistance to Antiangiogenic Therapy Neoplasia (New York, N.Y.). Jul, 2014 | Pubmed ID: 25117977 Marmosets As a Preclinical Model for Testing "off-label" Use of Doxycycline to Turn on Flt3L Expression from High-capacity Adenovirus Vectors Molecular Therapy. Methods & Clinical Development. Feb, 2014 | Pubmed ID: 25068145 Natural Killer Cells Eradicate Galectin-1-deficient Glioma in the Absence of Adaptive Immunity Cancer Research. Sep, 2014 | Pubmed ID: 25038230 Blocking Immunosuppressive Checkpoints for Glioma Therapy: the More the Merrier! Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014 | Pubmed ID: 24879798 The Value of EGFRvIII As the Target for Glioma Vaccines American Society of Clinical Oncology Educational Book / ASCO. American Society of Clinical Oncology. Meeting. 2014 | Pubmed ID: 24857059 Assessing the Role of STAT3 in DC Differentiation and Autologous DC Immunotherapy in Mouse Models of GBM PloS One. 2014 | Pubmed ID: 24806510 Adenoviral Vector-mediated Gene Therapy for Gliomas: Coming of Age Expert Opinion on Biological Therapy. Sep, 2014 | Pubmed ID: 24773178 Lentiviral-induced High-grade Gliomas in Rats: the Effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jul, 2014 | Pubmed ID: 24752661 Preclinical Characterization of Signal Transducer and Activator of Transcription 3 Small Molecule Inhibitors for Primary and Metastatic Brain Cancer Therapy The Journal of Pharmacology and Experimental Therapeutics. Jun, 2014 | Pubmed ID: 24696041 Temozolomide Does Not Impair Gene Therapy-mediated Antitumor Immunity in Syngeneic Brain Tumor Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2014 | Pubmed ID: 24501391 Dendritic Cell-based Immunotherapy for Glioma: Multiple Regimens and Implications in Clinical Trials Neurologia Medico-chirurgica. 2013 | Pubmed ID: 24140772 Neuro-oncology: The Long and Winding Road--gene Therapy for Glioma Nature Reviews. Neurology. Nov, 2013 | Pubmed ID: 24061435 Effectiveness and Preclinical Safety Profile of Doxycycline to Be Used "off-label" to Induce Therapeutic Transgene Expression in a Phase I Clinical Trial for Glioma Human Gene Therapy. Clinical Development. Sep, 2013 | Pubmed ID: 24007469 Progress in Gene Therapy for Neurological Disorders Nature Reviews. Neurology. May, 2013 | Pubmed ID: 23609618 Safety Profile, Efficacy, and Biodistribution of a Bicistronic High-capacity Adenovirus Vector Encoding a Combined Immunostimulation and Cytotoxic Gene Therapy As a Prelude to a Phase I Clinical Trial for Glioblastoma Toxicology and Applied Pharmacology. May, 2013 | Pubmed ID: 23403069 Gene Therapy-mediated Reprogramming Tumor Infiltrating T Cells Using IL-2 and Inhibiting NF-κB Signaling Improves the Efficacy of Immunotherapy in a Brain Cancer Model Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2012 | Pubmed ID: 22996231 Plasmacytoid Dendritic Cells in the Tumor Microenvironment: Immune Targets for Glioma Therapeutics Neoplasia (New York, N.Y.). Aug, 2012 | Pubmed ID: 22952428 Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal Brain Parenchyma: Implications for a Glioma Phase 1 Clinical Trial Human Gene Therapy Methods. Aug, 2012 | Pubmed ID: 22950971 Gene Therapy for Brain Tumors: Basic Developments and Clinical Implementation Neuroscience Letters. Oct, 2012 | Pubmed ID: 22906921 Cytotoxic Immunological Synapses Do Not Restrict the Action of Interferon-γ to Antigenic Target Cells Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22547816 Pushing the Limits of Glioma Resection Using Electrophysiologic Brain Mapping Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2012 | Pubmed ID: 22529267 Immune-mediated Loss of Transgene Expression from Virally Transduced Brain Cells is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and Due to the Elimination of Transduced Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2012 | Pubmed ID: 22233583 B Cells Are Critical to T-cell-mediated Antitumor Immunity Induced by a Combined Immune-stimulatory/conditionally Cytotoxic Therapy for Glioblastoma Neoplasia (New York, N.Y.). Oct, 2011 | Pubmed ID: 22028620 Identification and Visualization of CD8+ T Cell Mediated IFN-γ Signaling in Target Cells During an Antiviral Immune Response in the Brain PloS One. 2011 | Pubmed ID: 21897844 Targeted Toxins for Glioblastoma Multiforme: Pre-clinical Studies and Clinical Implementation Anti-cancer Agents in Medicinal Chemistry. Oct, 2011 | Pubmed ID: 21707497 Engineering the Brain Tumor Microenvironment Enhances the Efficacy of Dendritic Cell Vaccination: Implications for Clinical Trial Design Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2011 | Pubmed ID: 21632862 Moving Forward Toward a Cure for Parkinson's: Neuropathology of the Nigrostriatal Pathway Determines the Location of Growth Factor Delivery Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2011 | Pubmed ID: 21532611 Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 21505426 Gene Therapy and Targeted Toxins for Glioma Current Gene Therapy. Jun, 2011 | Pubmed ID: 21453286 AAV6-mediated Gene Silencing FALS Short Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011 | Pubmed ID: 21289637 Gene Therapy and Virotherapy: Novel Therapeutic Approaches for Brain Tumors Discovery Medicine. Oct, 2010 | Pubmed ID: 21034670 Gene Therapy-mediated Delivery of Targeted Cytotoxins for Glioma Therapeutics Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21030678 Cancer Vaccines in Glioma: How to Balance the Challenges of Small Trials, Efficiency, and Potential Adverse Events Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2010 | Pubmed ID: 20921460 Exogenous Fms-like Tyrosine Kinase 3 Ligand Overrides Brain Immune Privilege and Facilitates Recognition of a Neo-antigen Without Causing Autoimmune Neuropathology Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20660723 Human Flt3L Generates Dendritic Cells from Canine Peripheral Blood Precursors: Implications for a Dog Glioma Clinical Trial PloS One. 2010 | Pubmed ID: 20552015 A Novel Bicistronic High-capacity Gutless Adenovirus Vector That Drives Constitutive Expression of Herpes Simplex Virus Type 1 Thymidine Kinase and Tet-inducible Expression of Flt3L for Glioma Therapeutics Journal of Virology. Jun, 2010 | Pubmed ID: 20375153 Anti-tumor Immune Response Correlates with Neurological Symptoms in a Dog with Spontaneous Astrocytoma Treated by Gene and Vaccine Therapy Vaccine. Apr, 2010 | Pubmed ID: 20197146 Gene Transfer into Rat Brain Using Adenoviral Vectors Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [et Al.]. Jan, 2010 | Pubmed ID: 20066657 Risk in Clinical Research: Size Matters! Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2009 | Pubmed ID: 19876046 Gene Therapy for Brain Cancer: Combination Therapies Provide Enhanced Efficacy and Safety Current Gene Therapy. Oct, 2009 | Pubmed ID: 19860655 Uncertainty in the Translation of Preclinical Experiments to Clinical Trials. Why Do Most Phase III Clinical Trials Fail? Current Gene Therapy. Oct, 2009 | Pubmed ID: 19860651 Gene Therapy Continues to Make Progress: Clinical and Regulatory Perspectives Current Gene Therapy. Oct, 2009 | Pubmed ID: 19860647 Challenges in the Evaluation, Consent, Ethics and History of Early Clinical Trials - Implications of the Tuskegee 'trial' for Safer and More Ethical Clinical Trials Current Opinion in Molecular Therapeutics. Oct, 2009 | Pubmed ID: 19806495 Antiglioma Immunological Memory in Response to Conditional Cytotoxic/immune-stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009 | Pubmed ID: 19789315 Infiltrating CTLs in Human Glioblastoma Establish Immunological Synapses with Tumorigenic Cells The American Journal of Pathology. Aug, 2009 | Pubmed ID: 19628762 Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 19570774 HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression PLoS Medicine. Jan, 2009 | Pubmed ID: 19143470 Crossing the Rubicon Nature Biotechnology. Jan, 2009 | Pubmed ID: 19131996 Gene Transfer into Neural Cells in Vitro Using Adenoviral Vectors Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [et Al.]. Oct, 2008 | Pubmed ID: 18972378 A Call for Physiopathological Ethics Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2008 | Pubmed ID: 18956015 Clinical Trials in Gene Therapy: Ethics of Informed Consent and the Future of Experimental Medicine Current Opinion in Molecular Therapeutics. Oct, 2008 | Pubmed ID: 18830917 T Cells' Immunological Synapses Induce Polarization of Brain Astrocytes in Vivo and in Vitro: a Novel Astrocyte Response Mechanism to Cellular Injury PloS One. 2008 | Pubmed ID: 18714338 CD20, CD3, and CD40 Ligand Microclusters Segregate Three-dimensionally in Vivo at B-cell-T-cell Immunological Synapses After Viral Immunity in Primate Brain Journal of Virology. Oct, 2008 | Pubmed ID: 18684835 With a Little Help from My F(X)riends!: the Basis of Ad5-mediated Transduction of the Liver Revealed Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2008 | Pubmed ID: 18500239 Regulated Expression of Adenoviral Vectors-based Gene Therapies: Therapeutic Expression of Toxins and Immune-modulators Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18470649 Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials PloS One. 2008 | Pubmed ID: 18431473 Gene Delivery to the Nervous System Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2008 | Pubmed ID: 18362921 Turning the Gene Tap Off; Implications of Regulating Gene Expression for Cancer Therapeutics Molecular Cancer Therapeutics. Mar, 2008 | Pubmed ID: 18347132 High-capacity Adenovirus Vector-mediated Anti-glioma Gene Therapy in the Presence of Systemic Antiadenovirus Immunity Journal of Virology. May, 2008 | Pubmed ID: 18287240 Flt3L in Combination with HSV1-TK-mediated Gene Therapy Reverses Brain Tumor-induced Behavioral Deficits Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2008 | Pubmed ID: 18283279 In Vivo Polarization of IFN-gamma at Kupfer and Non-Kupfer Immunological Synapses During the Clearance of Virally Infected Brain Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2008 | Pubmed ID: 18209028 Immunization Against the Transgene but Not the TetON Switch Reduces Expression from Gutless Adenoviral Vectors in the Brain Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2008 | Pubmed ID: 18180781 Flt3L and TK Gene Therapy Eradicate Multifocal Glioma in a Syngeneic Glioblastoma Model Neuro-oncology. Feb, 2008 | Pubmed ID: 18079358 Immune Responses to Adenovirus and Adeno-associated Vectors Used for Gene Therapy of Brain Diseases: the Role of Immunological Synapses in Understanding the Cell Biology of Neuroimmune Interactions Current Gene Therapy. Oct, 2007 | Pubmed ID: 17979681 Immunology of Neurological Gene Therapy: How T Cells Modulate Viral Vector-mediated Therapeutic Transgene Expression Through Immunological Synapses Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2007 | Pubmed ID: 17920552 One-year Expression from High-capacity Adenoviral Vectors in the Brains of Animals with Pre-existing Anti-adenoviral Immunity: Clinical Implications Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2007 | Pubmed ID: 17895861 Improved Distribution of Small Molecules and Viral Vectors in the Murine Brain Using a Hollow Fiber Catheter Journal of Neurosurgery. Sep, 2007 | Pubmed ID: 17886557 Intracranial Glioblastoma Models in Preclinical Neuro-oncology: Neuropathological Characterization and Tumor Progression Journal of Neuro-oncology. Nov, 2007 | Pubmed ID: 17874037 Efficacy of Nonviral Gene Transfer in the Canine Brain Journal of Neurosurgery. Jul, 2007 | Pubmed ID: 17639883 Optimization of Adenoviral Vector-mediated Transgene Expression in the Canine Brain in Vivo, and in Canine Glioma Cells in Vitro Neuro-oncology. Jul, 2007 | Pubmed ID: 17522335 Adenoviral-mediated Gene Transfer into the Canine Brain in Vivo Neurosurgery. Jan, 2007 | Pubmed ID: 17228266 Immunological Thresholds in Neurological Gene Therapy: Highly Efficient Elimination of Transduced Cells Might Be Related to the Specific Formation of Immunological Synapses Between T Cells and Virus-infected Brain Cells Neuron Glia Biology. Nov, 2006 | Pubmed ID: 18084640 Immune Regulation of Transgene Expression in the Brain: B Cells Regulate an Early Phase of Elimination of Transgene Expression from Adenoviral Vectors Viral Immunology. 2006 | Pubmed ID: 16987068 In Vivo Mature Immunological Synapses Forming SMACs Mediate Clearance of Virally Infected Astrocytes from the Brain The Journal of Experimental Medicine. Sep, 2006 | Pubmed ID: 16923851 Effective High-capacity Gutless Adenoviral Vectors Mediate Transgene Expression in Human Glioma Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2006 | Pubmed ID: 16798098 Rapid Upregulation of Interferon-regulated and Chemokine MRNAs Upon Injection of 108 International Units, but Not Lower Doses, of Adenoviral Vectors into the Brain Journal of Virology. Jun, 2006 | Pubmed ID: 16699048 Fms-like Tyrosine Kinase 3 Ligand Recruits Plasmacytoid Dendritic Cells to the Brain Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16517725 Regulatable Gutless Adenovirus Vectors Sustain Inducible Transgene Expression in the Brain in the Presence of an Immune Response Against Adenoviruses Journal of Virology. Jan, 2006 | Pubmed ID: 16352528 Gene Therapy and Targeted Toxins for Glioma Current Gene Therapy. Dec, 2005 | Pubmed ID: 16457645 Platelets Mediate Cytotoxic T Lymphocyte-induced Liver Damage Nature Medicine. Nov, 2005 | Pubmed ID: 16258538 Combining Cytotoxic and Immune-mediated Gene Therapy to Treat Brain Tumors Current Topics in Medicinal Chemistry. 2005 | Pubmed ID: 16248789 Combined Immunostimulation and Conditional Cytotoxic Gene Therapy Provide Long-term Survival in a Large Glioma Model Cancer Research. Aug, 2005 | Pubmed ID: 16103070 Mutagenesis-induced, Large Fitness Variations with an Invariant Arenavirus Consensus Genomic Nucleotide Sequence Journal of Virology. Aug, 2005 | Pubmed ID: 16051837 The Case for Immunosuppression in Clinical Gene Transfer Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2005 | Pubmed ID: 16002339 Stability of Lentiviral Vector-mediated Transgene Expression in the Brain in the Presence of Systemic Antivector Immune Responses Human Gene Therapy. Jun, 2005 | Pubmed ID: 15960605 Inflammatory and Anti-glioma Effects of an Adenovirus Expressing Human Soluble Fms-like Tyrosine Kinase 3 Ligand (hsFlt3L): Treatment with HsFlt3L Inhibits Intracranial Glioma Progression Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2004 | Pubmed ID: 15564139 The Collaborative Cross, a Community Resource for the Genetic Analysis of Complex Traits Nature Genetics. Nov, 2004 | Pubmed ID: 15514660 Effects of Ectopic Decorin in Modulating Intracranial Glioma Progression in Vivo, in a Rat Syngeneic Model Cancer Gene Therapy. Nov, 2004 | Pubmed ID: 15475879 Input Virion Proteins: Cryptic Targets of Antivector Immune Responses in Preimmunized Subjects Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2004 | Pubmed ID: 15222326 Development of a Novel Helper-dependent Adenovirus-Epstein-Barr Virus Hybrid System for the Stable Transformation of Mammalian Cells Journal of Virology. Jun, 2004 | Pubmed ID: 15163748 Gene Therapy for Liver Transplantation Using Adenoviral Vectors: CD40-CD154 Blockade by Gene Transfer of CD40Ig Protects Rat Livers from Cold Ischemia and Reperfusion Injury Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2004 | Pubmed ID: 14741776 Adenovirus-mediated Gene Transfer of Transforming Growth Factor-beta3, but Not Transforming Growth Factor-beta1, Inhibits Constrictive Remodeling and Reduces Luminal Loss After Coronary Angioplasty Circulation. Dec, 2003 | Pubmed ID: 14638551 Nonneurotropic Adenovirus: a Vector for Gene Transfer to the Brain and Gene Therapy of Neurological Disorders International Review of Neurobiology. 2003 | Pubmed ID: 12968530 Adenovirus Expression of IL-1 and NF-kappaB Inhibitors Does Not Inhibit Acute Adenoviral-induced Brain Inflammation, but Delays Immune System-mediated Elimination of Transgene Expression Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2003 | Pubmed ID: 12946313 Use of Recombinant Adenovirus for Gene Transfer into the Rat Brain. Evaluation of Gene Transfer Efficiency, Toxicity, and Inflammatory and Immune Reactions Methods in Molecular Medicine. 2003 | Pubmed ID: 12526161 Adenovirus Vector-mediated Delivery of the Prodrug-converting Enzyme Carboxypeptidase G2 in a Secreted or GPI-anchored Form: High-level Expression of This Active Conditional Cytotoxic Enzyme at the Plasma Membrane Cancer Gene Therapy. Nov, 2002 | Pubmed ID: 12386828 Progress and Challenges in Viral Vector-mediated Gene Transfer to the Brain Current Opinion in Molecular Therapeutics. Aug, 2002 | Pubmed ID: 12222874 Dendritic Cells and Immune Responses in the Central Nervous System Trends in Immunology. Feb, 2002 | Pubmed ID: 11956012 Adenovirus Binding to the Coxsackievirus and Adenovirus Receptor or Integrins is Not Required to Elicit Brain Inflammation but is Necessary to Transduce Specific Neural Cell Types Journal of Virology. Apr, 2002 | Pubmed ID: 11884569 Prolonged Blockade of CD40-CD40 Ligand Interactions by Gene Transfer of CD40Ig Results in Long-term Heart Allograft Survival and Donor-specific Hyporesponsiveness, but Does Not Prevent Chronic Rejection Journal of Immunology (Baltimore, Md. : 1950). Feb, 2002 | Pubmed ID: 11823487 Immunology of Viral-vector-mediated Gene Transfer into the Brain: an Evolutionary and Developmental Perspective Trends in Immunology. Jan, 2002 | Pubmed ID: 11801451 Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures Felipe J. Núñez1,2, Flor M. Mendez2, Maria B. Garcia-Fabiani1,2, Joaquín Pardo1,3, Marta Edwards1,2, Pedro R. Lowenstein1,2, Maria G. Castro1,2 1Department of Neurosurgery, University of Michigan Medical School, 2Department of Cell & Developmental Biology, University of Michigan, 3INIBIOLP, Histology B-Pathology B, School of Medicine, UNLP JoVE 58931 Cancer Research Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres Flor M. Mendez1, Felipe J. Núñez1,2, Rocío I. Zorrilla-Veloz3,4, Pedro R. Lowenstein1,2, Maria G. Castro1,2 1Department of Cell and Developmental Biology, University of Michigan Medical School, 2Department of Neurosurgery, University of Michigan Medical School, 3Cancer Research Summer Internship Program (CARSIP), Cancer Biology Program, University of Michigan Medical School, 4Department of Biology, University of Puerto Rico-Río Piedras Campus JoVE 57016 Cancer Research Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells Gregory J. Baker1,2, Maria G. Castro1,2, Pedro R. Lowenstein1,2 1Department of Neurosurgery, University of Michigan, 2Department of Cell and Developmental Biology, University of Michigan JoVE 53676 Immunology and Infection Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma Anda-Alexandra Calinescu1, Felipe Javier Núñez1, Carl Koschmann2, Bradley L. Kolb1, Pedro R. Lowenstein1,3, Maria G. Castro1,3 1Department of Neurosurgery, University of Michigan School of Medicine, 2Department of Pediatrics, Division of Hematology-Oncology, University of Michigan School of Medicine, 3Department of Cell and Developmental Biology, University of Michigan JoVE 52443 Medicine
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures Felipe J. Núñez1,2, Flor M. Mendez2, Maria B. Garcia-Fabiani1,2, Joaquín Pardo1,3, Marta Edwards1,2, Pedro R. Lowenstein1,2, Maria G. Castro1,2 1Department of Neurosurgery, University of Michigan Medical School, 2Department of Cell & Developmental Biology, University of Michigan, 3INIBIOLP, Histology B-Pathology B, School of Medicine, UNLP JoVE 58931 Cancer Research
Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres Flor M. Mendez1, Felipe J. Núñez1,2, Rocío I. Zorrilla-Veloz3,4, Pedro R. Lowenstein1,2, Maria G. Castro1,2 1Department of Cell and Developmental Biology, University of Michigan Medical School, 2Department of Neurosurgery, University of Michigan Medical School, 3Cancer Research Summer Internship Program (CARSIP), Cancer Biology Program, University of Michigan Medical School, 4Department of Biology, University of Puerto Rico-Río Piedras Campus JoVE 57016 Cancer Research
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells Gregory J. Baker1,2, Maria G. Castro1,2, Pedro R. Lowenstein1,2 1Department of Neurosurgery, University of Michigan, 2Department of Cell and Developmental Biology, University of Michigan JoVE 53676 Immunology and Infection
Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma Anda-Alexandra Calinescu1, Felipe Javier Núñez1, Carl Koschmann2, Bradley L. Kolb1, Pedro R. Lowenstein1,3, Maria G. Castro1,3 1Department of Neurosurgery, University of Michigan School of Medicine, 2Department of Pediatrics, Division of Hematology-Oncology, University of Michigan School of Medicine, 3Department of Cell and Developmental Biology, University of Michigan JoVE 52443 Medicine
