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Reprimir a transcrição do Gene redirecionando maquinaria celular com modificadores epigenéticas químicas

Article DOI: 10.3791/58222-v • 10:28 min • September 20th, 2018
September 20th, 2018 •
1, 2, 3, 3, 4
1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina

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Regulamento do ambiente da cromatina é um processo essencial, necessário para a expressão do gene apropriado. Aqui, descrevemos um método para controlar a expressão do gene através do recrutamento de cromatina-modificando máquinas de forma gene-específico e reversível.

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Bioengenharia moléculas bifuncionais edição 139 biologia química química induzida por proximidade regulamento de cromatina repressão do gene histona deacetilase epigenética químicas modificadores epigenéticas CEMs
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