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Neuroscience

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JoVE Journal Neuroscience
Elektroforetisk leverans av γ-aminosmörsyra (GABA) till epileptiska fokus förhindrar kramper hos möss
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Elektroforetisk leverans av γ-aminosmörsyra (GABA) till epileptiska fokus förhindrar kramper hos möss

Article DOI: 10.3791/59268-v • 07:01 min • May 16th, 2019
May 16th, 2019 •
*1,5, *2,3, 1,4, 2,3, 1,5
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division, University of Cambridge, 3Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged
* These authors contributed equally

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요약
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Utmaningen med epilepsi forskning är att utveckla nya behandlingar för patienter där klassisk terapi är otillräcklig. Med hjälp av ett nytt protokoll-med hjälp av en implanterbara läkemedel leverans system-vi kan kontrol lera kramper i bedövade möss av den elektroforetiska leveransen av GABA i epileptiska fokus.

Tags

Neurovetenskap mikroflödessystem Ion pump μfip elektrofores epilepsi kramp anfall epileptiska fokus GABA Hippocampus kisel sond 4-aminopyridine 4ap mus
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