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Syngeneic mus ortotopiske allotransplantater til model kræft i bugspytkirtlen

Article DOI: 10.3791/64253-v • 06:20 min • October 4th, 2022
October 4th, 2022 •
1,2,3, 1,2,3,4, *1,2,3, *1,2,3
1Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 2Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 3Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, 4Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich
* These authors contributed equally

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Syngeneic mus ortotopiske allotransplantater af pancreas ductal adenocarcinom (PDAC) rekapitulerer biologi, fænotyper og terapeutiske reaktioner af sygdomsundertyper. På grund af deres hurtige, reproducerbare tumorprogression anvendes de i vid udstrækning i prækliniske undersøgelser. Her viser vi almindelig praksis for at generere disse modeller og injicere syngeneic murine PDAC-kulturer i bugspytkirtlen.

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Kræftforskning udgave 188 bugspytkirtel ortopisk implantation allograft pancreas ductal adenocarcinom tumormikromiljø behandling
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