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Aloinjertos ortotópicos singénicos de ratón para modelar el cáncer de páncreas

Article DOI: 10.3791/64253-v • 06:20 min • October 4th, 2022
October 4th, 2022 •
1,2,3, 1,2,3,4, *1,2,3, *1,2,3
1Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 2Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 3Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, 4Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich
* These authors contributed equally

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Los aloinjertos ortotópicos singénicos de ratón del adenocarcinoma ductal pancreático (PDAC) recapitulan la biología, los fenotipos y las respuestas terapéuticas de los subtipos de enfermedades. Debido a su progresión tumoral rápida y reproducible, son ampliamente utilizados en estudios preclínicos. Aquí, mostramos prácticas comunes para generar estos modelos, inyectando cultivos singénicos murinos de PDAC en el páncreas.

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Investigación del cáncer Número 188 Páncreas implantación ortotópica aloinjerto adenocarcinoma ductal pancreático microambiente tumoral tratamiento
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