Staff Science Editors
JoVE’s editorial team consists of scientists with expertise in each of the journal’s sections. Editors draw from their research experience to curate high-quality content for the journal. As a team, they ensure that JoVE’s content meets the highest standards of scientific validity and represents a complete library of methodologies across all areas of the physical and life sciences. JoVE’s editors share a vision of accelerating scientific progress by increasing reproducibility and productivity through video publishing. To learn more about the individual research backgrounds and interests of JoVE’s editorial team, see below.
Senior Science Editor
Benjamin graduated from the University of Delaware Magna Cum Laude with a B.S. in Chemistry and a minor in Biochemistry. During college, he founded and served as president of the fishing club, volunteered in the Dominican Republic, and interned for the National Park Service at Richmond National Battlefield Park.
Benjamin has researched and published in chemistry and bio-medical fields. His experience ranges from organic synthesis of antivirals to characterizing mouse models for cutaneous photodamage and autoimmune disease.
In his free time, Benjamin can be found boating and fishing, birdwatching, playing soccer, or carving wood.
Indrani Mukherjee, Ph.D.
Senior Science Editor
Indrani completed her PhD in Biochemistry from Dartmouth College, Hanover, NH. During her thesis work, she investigated the role of specific membrane proteins in the early secretory pathway using molecular biology, genetic and biochemical approaches. She is inspired by the innovative culture at JoVE and loves learning more about exciting research being carried out by scientists across the world. Outside of work, Indrani enjoys reading, traveling and salsa dancing.
Jaydev Upponi, Ph.D.
Jaydev is a native of Mumbai (Bombay), India. He graduated with a Bachelors in Pharmaceutical Sciences from Bombay College of Pharmacy, University of Mumbai. He moved to Boston and graduated with his Masters from Northeastern University. While at Northeastern, Jaydev developing a passion for research and later graduated with a Ph.D in Pharmaceutical Sciences. During his Ph.D, Jaydev developed and characterized various nano-based pharmaceutical preparations for application as therapeutics and diagnostics in oncology. Outside the lab, he actively took part in organizing and promoting student club activities such as the NU-AAPS and volunteering for the European Career Fair. His hobbies are cooking, listening to music and reading. Jaydev is excited to be a part of JoVE and believes that JoVE’s innovative approach to science-publication will revolutionize research across industry and academia.
Jialan Zhang, Ph.D.
Jialan received her Ph.D. in Materials Science and Engineering from University of Connecticut in 2013. Jialan first discovered JoVE while conducting her postdoctoral research at the Department of Physics and Astronomy in Rutgers University. She joined JoVE in 2016, and in her spare time she likes to read, chat with family and friends, and travel.
Lyndsay Troyer, Ph.D.
Lyndsay joined JoVE as the editor of the Environment section in 2016 following a position as a postdoctoral researcher in the Earth and Planetary Sciences department at Washington University in St. Louis. She received a B.A. in Chemistry at Whitman College and completed her Ph.D. in Analytical Chemistry at Colorado State University. During her Ph.D., Lyndsay studied arsenic and uranium biogeochemistry in mine tailing sediments. She continued her research on uranium geochemistry, primarily using synchrotron-based X-ray techniques, during her postdoc.
Aaron Berard, Ph.D.
Aaron graduated from the University of Massachusetts Amherst with a B.S. in Psychology and a minor in Neuroscience. During college, he worked as a research assistant for a cognition lab where he developed his passion for neuroscience and honed his interest to the study of brain plasticity. Aaron received his Ph.D. in Cognitive Science from Brown University four years after his graduation from Umass, where he studied the effect of sleep on the consolidative plastic mechanisms in the brain. He then pursued his postdoctoral research at a neighboring lab in Brown where he investigated potential interventions for Alzheimer’s disease using integrative cognitive techniques. In his free time, Aaron enjoys playing drums, guitar, and piano as well as practicing his cooking skills.
Ronald Myers, Ph.D.
Senior Science Editor
Ron received his Ph.D. in cellular, molecular, and developmental biology from Tufts University. During his thesis work he investigated the role of various extracellular matrix proteins in the proliferation and migration of vascular smooth muscle cells. After graduating from Tufts, Ron began a postdoctoral research position at Harvard Medical School. His research focused on the role of a novel class of arrestins, the α-arrestins, on β-adrenergic receptors in the context of heart failure and obesity. In his spare time Ron is an animal lover and enjoys camping and the outdoors.
Nandita Singh, Ph.D.
Senior Science Editor
Dr. Singh holds a Ph.D. in Biological Sciences from University of South Carolina, Columbia and a M.Sc. in Molecular Biology from the Indian Institute of Technology in Roorkee, India. Nandita completed her post-doctoral work at the Whitehead Institute and worked in the Biotech Industry for over two years. She has published in leading journals including Nature, Nature Genetics, Genes and Development and Current Biology. She is convinced that the power of the visual media far exceeds the written word especially when it comes to describing biological methods. In her opinion, video protocols are an invaluable tool to make challenging biological techniques more reproducible and accessible to the entire scientific community.
JoVE’s Editorial Board includes world-renowned professors, scientists, physicians and key opinion leaders. Board members have been selected for their knowledge and proven experience in experimental science and/or cutting-edge medical practice. Our Board Members share the JoVE vision to accelerate scientific research through enhanced transparency and technical excellence at the lab bench and in the clinic. Editorial Board members act as advisors for the content, scope and long-term editorial vision of the journal.
Jean-Christophe BilleterAssociate Professor
Faculty of Science and EngineeringUniversity of Groningen BiographyJean-Christophe Billeter is a neurogeneticist with training in behavioral biology, molecular genetics, pheromonal communication and neurobiology. The key question in his work is how genes and the environment interact at the mechanistic level to influence behavior. He seeks to answer this question by using the genetics of the fruit fly Drosophila melanogaster has a gateway to the molecules and cells that control behavior. His group has a particular emphasis on the mechanisms underlying social and sexual behaviors, but also works on ultimate questions such as the evolution of parental effects and the impact of ecological interactions in the evolution of reproductive behaviors.
Department of Family Health Care NursingUniversity of California San Francisco BiographyDr. Franck holds the Jack and Elaine Koehn Endowed Chair in Pediatric Nursing at the University of California, San Francisco (UCSF) School of Nursing and is the Co-Principal Investigator - California, for the UCSF Preterm Birth Initiative (PTBi). The PTBi is a multi-year, transdisciplinary research and implementation initiative to reduce the burden of preterm birth, funded by the Marc and Lynne Benioff and the Bill and Melinda Gates foundations and led by UCSF (www.pretermbirth.ucsf.edu). In addition to providing strategic leadership for the Initiative, she currently leads multiple transdisciplinary research teams within the Initiative, working in partnership with community and service provider stakeholders, to conduct research aimed at reducing disparities in health care access and health outcomes for women at risk for preterm birth and preterm infants. Dr. Franck has extensive research experience in maternal child health and development as well as in hospital quality and safety and ethics related to pediatric healthcare. She has over 200 peer-reviewed research and review publications on a wide range of topics, including maternal and child health and development and ethics. Findings from her research have influenced the neonatal and pediatric healthcare and health policy worldwide. Dr. Franck received her bachelor’s degree in nursing from the University of San Francisco and her master’s degree and PhD in nursing from UCSF. She rejoined the UCSF faculty in 2010, after a decade at the University College London, Institute of Child Health where she was the first Chair of Children’s Nursing Research in the UK.
Giuseppe GiannaccareAssistant Professor
Department of Experimental, Diagnostic and Specialty MedicineUniversity of BolognaBiographyGiuseppe Giannaccare, M.D., Ph.D., is an Italian Ophthalmologist who earned his Medical Degree at University of Rome “Campus Bio-Medico” in 2009, and completed his residency in Ophthalmology at University of Bologna in 2015.
In 2017 he got Ph.D. in Biomedical Sciences at the University of Bologna, defending a thesis on Ocular Graft-versus-Host disease.
Dr. Giannaccare is the author of several abstracts, papers and book chapters. He is also Editor and Reviewer for several International Journals focused on Ophthalmology and Medicine. Dr. Giannaccare is co-Author of the translations from English to Italian language of the American Academy of Ophthalmology Guidelines and is recipient of several International grants.
Currently, Dr. Giannaccare is serving as Researcher at the University of Bologna and Cornea and Anterior Segment Specialist at S.Orsola-Malpighi Hospital in Bologna (Italy). He belonged to Young Ophthalmologist Directive Committee of European Society of Ophthalmology (YO SOE) from 2015 to 2017, and currently he is National Representative for Italy for the YO SOE.
Benjamin NephewAssistant Professor
Department of Biomedical SciencesTufts University BiographyOur lab primarily studies a transgenerational social stress based rodent model of postpartum depression/anxiety. We are testing the effectiveness of intranasal oxytocin and vasopressin in preventing/treating maternal and offspring depression/anxiety and social deficits. Related clinical work also explores the role of oxytocin in postpartum depression/anxiety, with a specific focus on Latina populations. Current research includes the impact of social stress and air pollution on immune factors, neural connectivity, and epigenetic neuroendocrinology.
Uri ShalevAssociate Professor
Department of PsychologyConcordia UniversityBiographyUri Shalev received his Ph.D. in Psychology from Tel Aviv University. After completing his postdoctoral training with Dr. Yavin Shaham at the National Institute on Drug Abuse/NIH in 2002, he headed the behavioral laboratory in D-Pharm Ltd., Rehovot, Israel. At the same time, he was appointed a senior lecturer at the Academic College Tel Aviv-Yaffo. In 2004 he joined the Department of Psychology and the Center for Studies in Behavioral Neurobiology at Concordia University, where he is currently an Associate Professor. He held a Canada Research Chair in Neurobiology of Drug Abuse (Tier II; 2004-2015). His research involves two main themes: 1) Elucidating the brain mechanisms that underlie stress-induced relapse to drug abuse. 2) Comorbidity of drug abuse with eating disorders.
Devavani ChatterjeaAssociate Professor
Program in Community & Global HealthMacalester CollegeBiographyDevavani Chatterjea, Ph.D., MPH is a professor of biology at Macalester College, Saint Paul, MN. Her laboratory investigates the intersection of immunological mechanisms at the intersection of allergies and chronic pain. She develops and teaches innovative courses in immunology, immunological research methods and global environmental health.
Charles J. DimitroffAssociate Professor
Department of DermatologyHarvard Medical SchoolBiographyDr. Dimitroff is an Associate Professor of Dermatology and Associate Director for Laboratory Research in the Department of Dermatology at Brigham and Women’s Hospital/Harvard Medical School. His Laboratory studies the nature of lectin – carbohydrate interactions and their impact in inflammation and cancer. His expertise in glycobiology serves as a basis for in vitro and in vivo analyses on mechanisms of tumor progression and adaptive immune responses. The Core Principle of his Laboratory is to functionally characterize lectins and their carbohydrate-binding ligands on leukocytes and cancer cells. These interests span cell models, such as T cells, B cells, NK cells, leukemic/hematopoietic stem cells and solid cancer cells and pathways, including but not limited to trafficking (metastasis), adhesion, fate and differentiation.
Dr. Dimitroff’s Laboratory provides a nurturing training environment at Harvard Medical School for the next generation of immunology/cancer research scientists. He serves as a Faculty Member in Harvard Immunology Ph.D. Program and serves as the Director of the BWH Dermatology Scholarship Oversight Committee and Research Training Program.
Qiu-Xing JiangFaculty Director of Electron Microscopy
Interdisciplinary Center for Biotechnology Research (ICBR)University of FloridaBiographyDr. Jiang is currently leading the Laboratory of Molecular Biophysics and Cell Physiology at the Institute of Food and Agricultural Sciences of University of Florida (UF), and serves as a Faculty Director of Electron Microscopy at the Institute of Cross-disciplinary Biotechnology Research (ICBR) of UF. His current research is centered on lipid-dependent gating effects and molecular players in regulated secretion. Dr. Jiang obtained his Ph.D. in 2002 from the Department of Cellular and Molecular Physiology at Yale University School of Medicine, working with Dr. Frederick Sigworth. He initiated the implementation of spherically constrained reconstruction (SCR) by imaging membrane proteins in small vesicles. Dr. Jiang finished his postdoctoral training in molecular biophysics and structural biology with Dr. Roderick Mackinnon in 2007 before taking an Assistant Professorship position at UT Southwestern Medical Center at Dallas, Texas. While in Dallas, he worked on the development of chemically functionalized nm-thick carbon films, discovered the mechanism of filament-based signal amplification in the innate immune response against RNA viruses, studied membrane-induced pore formation by human C-type Lectin and VopQ proteins, and advanced the concept for lipid-dependent gating of Kv channels. He is the recipient of the NIH EUREKA award in 2009, the Junior Faculty travel award from GRC Molecular and Cell Biology of Lipids in 2011 and the AHA National Innovative Award in 2012.
Department of BiologyMassachusetts Institute of TechnologyBiographyHazel Sive is Professor of Biology at MIT, Member of the Whitehead Institute for Biomedical Research and Associate Member of the Broad Institute. She received the B.Sc. Hons. from University of Witwatersrand, Johannesburg, South Africa and the Ph.D. from Rockefeller University. Her groundbreaking research focuses on neurodevelopmental and mental health disorders, as well as fundamental processes underlying brain and craniofacial development. Dr. Sive also focuses on education and training. She is a MacVicar Faculty Fellow, MIT’s highest undergraduate teaching award. She teaches Introductory Biology to undergraduates and Developmental Biology to graduate students. She is former Associate Dean of Science with oversight for equity and education. Dr. Sive is Director of MIT-Africa, an initiative that promotes collaboration between MIT and Africa, and Director of Higher Education for the new Jameel World Education Lab (J-WEL) at MIT. She is committed to communicating to the powerful contributions that scientific research makes to health and society.
Harris BernsteinSenior Investigator
Genetics and Biochemistry BranchNational Institutes of HealthBiographyHarris Bernstein is a Senior Investigator in the Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive Diseases, National Institutes of Health (NIH) in Bethesda, Maryland. He received an undergraduate degree from Harvard University and a Ph.D. from MIT. Dr. Bernstein has a long-standing interest in understanding how proteins are translocated across or inserted into the membranes of both pathogenic and non-pathogenic bacteria. As a post-doctoral fellow in Peter Walter’s lab at the University of California at San Francisco he discovered a bacterial homolog of the signal recognition particle (SRP), an essential protein targeting factor that at the time was believed to exist only in mammalian cells. As an independent investigator at the NIH he continued to work on SRP and the Sec pathway in E. coli. He and his colleagues have also investigated the mechanism by which the expression of secA is regulated at the level of translation by ribosome stalling. His research group currently studies the assembly of bacterial outer membrane proteins and the secretion of virulence factors by a specialized pathway (the type V or “autotransporter” pathway) that is utilized by a wide variety of Gram-negative pathogens. Recently his group has also begun to investigate protein secretion in Bacteroides fragilis, a prominent member of the human gut microbiome.
Matthew E. CallAssociate Professor
Structural Biology DivisionThe Walter and Eliza Hall Institute of Medical ResearchBiographyMatthew Call received his Ph.D. in Immunology from Harvard University in 2007, where he worked on T cell receptor assembly and structure with Prof. Kai Wucherpfennig. After completing postdoctoral training in solution NMR with Prof. James Chou at Harvard Medical School, Call moved to Melbourne, Australia, where is currently Associate Professor and Joint Head of Structural Biology at the Walter and Eliza Hall Institute of Medical Research. His work is focused on understanding complex immune receptor structures and relating their architecture in the cell membrane to their signalling mechanisms. The lab uses solution NMR, X-ray crystallography, mutagenesis and biochemical cross-linking to build more comprehensive views of receptor structure and function.
Craig E. CameronProfessor
Department of Biochemistry and Molecular BiologyPennsylvania State UniversityBiographyCraig E. Cameron is the holder of the Eberly Family Chair in Biochemistry and Molecular Biology at The Pennsylvania State University. He earned a Bachelor of Science degree in chemistry from Howard University in 1987. Following doctoral studies in biochemistry at Case Western Reserve University School of Medicine and post-doctoral studies in the chemistry department at Penn State, Cameron joined the faculty of biochemistry and molecular biology at Penn State in 1997. He was tenured, promoted to the rank of associate professor and appointed Louis Martarano Associate Professor in 2002. In 2005, he was promoted to the rank of professor and named the Paul Berg Professor of Biochemistry and Molecular Biology. From 2011-2012, Cameron served a two-year term as Associate Head for Research and Graduate Education. In 2013, he was named holder of the Eberly Family Chair in Biochemistry and Molecular Biology. Cameron’s research focuses on RNA polymerases and RNA-binding proteins required for viral replication or mitochondrial function. The goal of this work is development of novel strategies to treat and/or prevent viral infections and mitochondrial dysfunction. He has trained nearly 100 undergraduate research students, more than a dozen graduate students and the same number of post-doctoral students. Together with his students, mentors and collaborators, Cameron has published on the order of 150 papers in highly regarded journals.
During his career, Dr. Cameron has received several honors, including the Howard Temin Award from the National Cancer Institute, an Established Investigator Award from the American Heart Association, a Distinguished Service Award from the Eberly College of Science Alumni Association and the Genesis Scholar Award from HBCU Digest, Fellow of the American Association for the Advancement of Science, and Fellow of the American Academy of Microbiology. He was a member of the Board of Scientific Counselors for the National Institute of Diabetes, Digestive and Kidney Diseases and served on the executive councils of the American Society for Microbiology, American Society for Virology, American Society for Biochemistry and Molecular Biology (ex officio), and as chair of the Minority Affairs Committee of ASBMB and a member of the Public Affairs Committee of ASBMB. Cameron currently serves on the National Science Advisory Board for Biosecurity, Molecular Genetics B Study Section and on the editorial boards for Journal of Biological Chemistry, Journal of Virology, Viruses and now JoVE.
A primary goal of the Cameron laboratory has been development of strategies to treat or to prevent infections by RNA viruses and diseases linked to mitochondrial dysfunction. His expertise in virology, biochemistry and mechanistic enzymology brings a unique combination of intellectual and technical resources to his research. Cameron’s work is highly collaborative and includes teams from academia (local, national and international), government and industry.
Institute of Physical ChemistryUniversity of FreiburgBiographyDr.Hugel's lab uses single molecule methods to investigate molecular machines and signaling in biological systems. They focus on understanding complex dynamic biological processes in and out of equilibrium. In addition, Dr. Hugel's lab probes the interaction between proteins and lipid bilayers. The core methods are single molecule multi-colour FRET and single molecule force spectroscopy.
John LaCavaAssistant Professor
Laboratory of Cellular and Structural BiologyThe Rockefeller UniversityBiographyJohn LaCava is a research-track assistant professor at The Rockefeller University and a Senior Researcher at the NIH's National Center for Dynamic Interactome Research. He earned a B.S. in biotechnology from UC Davis and a Ph.D. in molecular genetics from the University of Edinburgh. Dr. LaCava's research focuses on improving methods and technology for interactome analyses and applying such tools to tackle challenges in molecular and cell biology. For this, he frequently draws upon mass spectrometry-based affinity-proteomic techniques, with special emphasis on approaches that also enable downstream structural and biochemical studies of purified macromolecular complexes. Among other research interests, Dr. LaCava’s group studies the lifecycle of human LINE-1 retrotransposons and mechanisms of human RNA processing by the exosome.
Dirk-Jan ScheffersAssociate Professor
Faculty of Science and EngineeringUniversity of GroningenBiographyProf. Dirk-Jan Scheffers is a microbiologist (Ph.D. in 2001) with training in fluorescence microscopy and biochemistry. The key question in his work is: how do bacteria define and propagate their shape? Answers to this question are sought by studying the biochemistry of the bacterial cell division process, and by studying the mechanisms that regulate bacterial cell wall (peptidoglycan) synthesis. Using genetics, microscopy and biochemistry, Scheffers has made important contributions to the understanding of the essential division protein FtsZ - and frequently collaborates with other groups that require experience with FtsZ. Scheffers has also made contributions to the localization of Penicillin-Binding Proteins (PBP) that are key players in the peptidoglycan synthesis process. Scheffers' collection of GFP-fusions to PBPs has been used by B. subtilis labs worldwide. The main research areas include: 1)Peptidoglycan chemistry: elucidating local differences in the structure of peptidoglycan; 2)Positioning of cell wall synthesis proteins and their relation with membrane structure; 3)Characterization of novel antibacterials to combat the Gram-negative plant pathogen Xanthomonas citri.
Robin StanleyPrincipal Investigator
Signal Transduction LaboratoryNational Institute of Environmental Health SciencesBiographyRobin Stanley, Ph.D., heads the Nucleolar Integrity Group within the NIEHS Signal Transduction Laboratory. Stanley is an Earl Stadtman Tenure-Track Investigator and earned her B.S. in chemistry and B.A. in mathematics from the University of North Carolina at Charlotte. She earned her Ph.D. in molecular biophysics and biochemistry at Yale University, where she worked under Nobel Laureate Thomas Steitz, Ph.D. Before joining NIEHS in 2014, she was a postdoctoral fellow with James H. Hurley, Ph.D., at the National Institute of Diabetes, Digestive, and Kidney Diseases.
Taisuke Tomita Professor
Graduate School of Pharmaceutical SciencesUniversity of TokyoBiographyWe mainly use biochemistry and molecular biology to study molecular and cell pathology in both cultured cells and animal models, identify new technologies and new drug discovery targets, and deliver results that will lead to the development of therapeutic drugs, as well as aim to give new developments to basic biology research. We also actively pursue collaborative research with industry and academia, and aim for social implementation of research results.
Our group aims at findings leading to the development of therapeutic, preventive and diagnostic methods through fundamental disease research and at the same time we are conducting research with the goal of developing new basic research fields. We do so by identifying molecular causes of various diseases, especially neuropsychiatric disorders; elucidating the mechanism of diseases; and by identifying new drug targets and their molecule mechanisms.
Our research focuses on both the study and intervention of molecular pathology of diseases caused by abnormality of membrane protein metabolism. The main diseases being studied in our lab are: Alzheimer's disease, autism, and Parkinson's disease.
Douglas CowanAssociate Professor
Department of AnesthesiologyBoston Children's HospitalBiographyDouglas Cowan is an Associate Professor of Anaesthesia at Harvard Medical School and a Staff Scientist in the Department of Anesthesiology, Critical Care and Pain Medicine at Boston Children’s Hospital. His laboratory is developing cell-based therapies to treat heart disease in humans. Currently, they are focused on the following clinically-relevant research projects: 1) engineering tissue to function as a permanent atrioventricular electrical conduit as an alternative to pacemaker implantation in children with complete heart block, 2) designing methods to expand and direct the differentiation of stem cell populations to determine their regenerative potential for treatment of cardiac diseases, 3) assessing non-invasive, imaging modalities to serially track the retention, distribution, and function of transplanted cells in experimental therapeutic trials, and 4) transplanting mitochondria to the heart to decrease the extent of damage following an ischemic injury and enhance functional recovery.
Lali K. Medina-KauweProfessor
Department of Biomedical SciencesCedars-Sinai Medical CenterBiographyDr. Lali Medina-Kauwe received her Ph.D. in Molecular Biology from UCLA in 1995 and used her skills in molecular engineering to create the first modified recombinant adenoviral capsid protein as a nonviral gene and drug delivery agent. She has since demonstrated that this agent can deliver imaging and therapeutic cargo to tumors in a missile-like targeted fashion by mimicking an essential ligand internalized by cancer cells; but, like a Trojan Horse, releases tumoricidal attack once past the cell barrier. Her technologies have led to several issued and pending patents related to nanobiologic targeting. In 2014, she co-founded Eos Biosciences, a spin-off company that has licensed her technologies for clinical development, while she continues to serve as Scientific Advisor to Eos.
Dr. Medina-Kauwe joined the Cedars-Sinai research faculty in 2003, and has remained continuously funded by the NIH/NCI as well as receiving grant support from the Department of Defense, Komen Foundation, Avon Foundation, and the American Cancer Society. She has served as a scientific reviewer for nearly three-dozen NIH study section panel meetings since 2006, as well as numerous grant review panels for the Department of Defense, and international foundations. She has been an invited conference speaker for the American Chemical Society, the American Society of Gene and Cell Therapy, Cold Spring Harbor Vector Targeting Strategies, and International Congress of Biochemistry and Molecular Biology; and at other institutions, including U of Washington, Emory U, U Penn, U of Wisconsin - Madison, UCLA, USC School of Pharmaceutical Sciences, UC Fullerton, and Oregon Health Sciences U.
In 2013, Dr. Medina-Kauwe accepted an appointment as Co-Director of the Ph.D. program in Biomedical Sciences and Translational Medicine at Cedars-Sinai Medical Center.
Department of Electrical and Computer EngineeringUniversity of MinnesotaBiographySang-Hyun Oh obtained his B.S. in Physics from KAIST, Korea, and Ph.D. in Applied Physics from Stanford University. After postdoctoral research at Bell Laboratories, Murray Hill, and at the University of California at Santa Barbara, he joined the ECE department at the University of Minnesota-Twin Cities, in 2006. He currently holds the Sanford P. Bordeau Chair in Electrical Engineering and directs a lab focused on top-down nanofabrication, plasmonic biosensing, and biochemical spectroscopies.
Michael W. PlesniakProfessor
Department of Mechanical & Aerospace EngineeringGeorge Washington UniversityBiographyDr. Michael W. Plesniak is Professor and Chair of the Department of Mechanical & Aerospace Engineering at the George Washington University, with a secondary appointment in the Department of Biomedical Engineering. He is the Director of the GW Center for Biomimetics and Bioinspired Engineering. Prof. Plesniak earned his Ph.D. degree from Stanford University, and his M.S. and B.S degrees from the Illinois Institute of Technology; all in Mechanical Engineering. Dr. Plesniak is a Fellow of AIAA, ASME, APS, AIMBE and AAAS. He has authored over two hundred fifty refereed archival publications, conference papers and presentations. He has presented numerous invited seminars and keynote addresses. Prof. Plesniak received the 2017 ASME Fluids Engineering Award
Michael (Seungju) YuAssociate Professor
Department of BioengineeringUniversity of UtahBiographyDr. Yu is an associate professor of Bioengineering at the University of Utah, and a recipient of Presidential Early Career Award for Scientists and Engineers (PECASE) and NSF CAREER award. Previously, he was an associate professor of Materials Sci. & Eng. at the Johns Hopkins University. Dr. Yu received his doctoral degree in Polymer Science and Engineering from University of Massachusetts at Amherst working on liquid crystalline properties of recombinant proteins under the guidance of Prof. David Tirrell. Subsequently, he had post-doc training at the University of Wisconsin at Madison with Prof. Samuel H. Gellman, synthesizing novel surfactants, beta-peptides and poly(beta-amino acids). Dr. Yu’s research interests lie in the synthesis, characterization, and application of organic materials that are either inspired by, or derived from biological systems. In particular, his group has focused on applying principles of protein folding and assembly to development of a wide variety of materials that range from piezoelectric polymers to tissue engineering scaffolds and diagnostic/therapeutic molecules. Recently, Dr. Yu’s research group has developed a new peptide probe-based technology for targeting denatured collagens. This work is considered a breakthrough in collagen detection (published in over 20 peer-reviewed journals in the last 5 years, including PNAS, Nature Commnun. JACS) for its ability to specifically bind to collagens denatured by proteinase or by mechanical damage both in vitro and in vivo.
Cancer Research Section
Utkarsh AcharyaAssistant Professor
Division of Medical OncologyUniversity of WashingtonBiographyDr. Acharya is on faculty as an Assistant Member at Fred Hutchinson Cancer Research Center within the Clinical Research Division and serves as an Assistant Professor of Medicine within the Division of Medical Oncology at the University of Washington School of Medicine. His clinical expertise is in chimeric antigen receptor (CAR) T-cell therapy and his research interests include expanding the utility of adoptive T cell therapies across tumor types while optimizing clinical management of CAR T cell mediated toxicities.
He earned his medical degree from Ohio University in Athens, Ohio. He completed his internal medicine residency at The Ohio State University in Columbus and fellowship in hematology-oncology at The University of Arizona Cancer Center in Tucson, Arizona.
Dr Acharya is board certified by the American Board of Medical Specialties in Internal Medicine, Medical Oncology, and Hematology. He is an elected fellow of the American College of Physicians and is an inducted honoree of the Arnold P. Gold Humanism Honor Society as well as Alpha Omega Alpha Medical Honor Society. He serves on several editorial boards of peer reviewed publications and has published numerous articles in peer-reviewed journals including Clinical Lymphoma, Myeloma & Leukemia, JAMA Oncology, Journal of Hematology & Oncology, Journal of Clinical Oncology and Blood.
Inyeong ChoiAssociate Professor
Department of PhysiologyEmory UniversityBiographyDr. Inyeong Choi is an Associate Professor of Physiology at Emory University. He received a Ph.D in developmental biology from the University of Wisconsin. Dr. Choi completed a postdoctoral fellowship in Dr. Walter Boron's lab at Yale University and then joined the faculty of the Department of Physiology at Emory. He has the expertise in cellular and systemic pH regulation in various organ systems including the neural, cardiovascular, and renal systems. His research focuses on the sodium bicarbonate transporters that are essential for cellular pH maintenance in nonepithelial cells and transepithelial movement of bicarbonate in epitheliall cells. Abnormal functions of bicarbonate transporters result in human diseases and dysfunctional states including metabolic acidosis, stroke, seizure, and visual defects. In addition, recent studies show pathophysiological implication of bicarbonate transporters on cancer progression and drug addiction propensity. Dr. Choi's team hopes to gain knowledge of bicarbonate transporter-mediated physiology and pathology at multiple levels ranging from cellular, molecular to systemic levels, and develops therapeutic approaches toward acid-base imbalance that is associated with acute insults.
William M. GradyProfessor
Division of GastroenterologyUniversity of WashingtonBiographyDr. Grady is a molecular biologist and board-certified gastroenterologist. He is an independent NIH funded PI with >20 years of experience in translational research related to gastrointestinal cancer. He is a Co-Head of the GI Cancer Program of the Fred Hutchinson Cancer Research Center/University of Washington Comprehensive Cancer Center and the Director of Translational Research for the Gastroenterology Division at the University of Washington. Furthermore, Dr. Grady, in his role of a practicing gastroenterologist, manages patients with a variety of gastrointestinal diseases including Barretts esophagus, colon polyps and cancer. He is the Medical Director of the GI Cancer Prevention Program Clinic at the Seattle Cancer Care Alliance, which specializes in the care of individuals who have cancer family syndromes, including Lynch syndrome and polyposis syndromes. He is one of the PIs in the Barretts Esophagus Translational Research Network (BETRNet). He is also the PI of a multi-PI Early Detection Research Network (NCI) Biomarker Discovery Lab (co-PI S. Markowitz). His NCI funded projects assess the role of epigenetic alterations as risk markers and biomarkers for esophageal and colon cancer, respectively. He is conducting studies that: 1) determine the role of the genetic and epigenetic alterations in the initiation and progression of colorectal and esophageal cancer; 2) determine novel treatment approaches to colorectal cancer, and 3) identify molecular factors that influence the risk for colorectal cancer.
Wenwei HuAssociate Professor
Department of Radiation OncologyRutgers Cancer Institute of New JerseyBiographyWenwei Hu is Associate Professor of the Department of Radiation Oncology of Rutgers Cancer Institute of New Jersey at Rutgers University. Dr. Hu received M.B. degree from Zhejiang University School of Medicine and then received Ph.D. degree from same university for research on mutagenesis induced by chemical carcinogen. Dr. Hu had postdoctoral training at the NYU School of Medicine, focusing on DNA damage and repair. She then moved to UMDNJ continuing her postdoctoral training with Dr. Arnold Levine studying p53 and its signaling pathway. During this period, she discovered a novel physiological function of p53 in regulation of maternal implantation. Since 2008, she has been a faculty member at Rutgers Cancer Institute of New Jersey in New Brunswick, NJ. A major research interest of Dr. Hu’s group is to study the function and regulation of tumor suppressor p53, which in turn impacts upon tumorigenesis. Her group discovered that chronic psychological stress impairs wild type p53 function, which contributes to the promoting effect of chronic stress on tumorigenesis. The work from her group also made important contribution to understand the mechanisms of mutant p53 accumulation and gain of oncogenic activity in tumors. In addition, Dr. Hu studies the function of LIF, a cytokine that is a p53 target, in tumorigenesis.
Shioko KimuraSenior Investigator
Head of Endocrinology SectionNational Institutes of Health BiographyDr. Kimura obtained her Ph.D. in chemistry at Hokkaido University in Sapporo, Japan. After postdoctoral studies at Queen's University, Kingston, Ontario and the National Institute of Child Health and Human Development as a visiting fellow, she moved to the Laboratory of Molecular Carcinogenesis at the National Cancer Institute (NCI). Since 1996, she has been the Head of the Endocrinology Section in the Laboratory of Metabolism. Dr. Kimura’s research focuses on understanding the role of homeodomain transcription factor NKX2-1, a master transcription factor in thyroid development and a marker for lung adenocarcinoma in humans, and its downstream target, a novel cytokine, secretoglobin (SCGB) 3A2, in development, homeostasis, physiology, and pathogenesis of diseases, particularly cancers of the thyroid and lung. Dr. Kimura uses cell culture and mouse models, and various genetically engineered mouse lines to investigate these problems.
Zhaoyu LiAssistant Professor
Cancer Genomics LaboratoryMayo Clinic BiographyResearch focus: genomics, epigenomics, cancer, stem cell biology and tissue development, sexual dimorphism, bioinformatics.
Dr. Li's lab is performing a comparative genomics study of Foxa/ERa dual targets between liver cancer and breast cancer in mouse models using genomic and proteomic approaches, such as next-generation sequencing and mass spectrometry. The lab is also interested in translating the information obtained from its mouse studies into human cancers and testing target genes for therapeutics of both cancers.
Next-generation sequencing technology allows Dr. Li and his colleagues to reveal detailed chromatin structures in the whole genome, which provides novel scenarios of gene regulation compared to traditional approaches. They are also interested in identifying the genomic and epigenomic landscapes in regulating stem cell differentiation and their impact on cancer progression using genomic and bioinformatics approaches.
Raul MostoslavskyAssociate Professor
MGH Cancer CenterHarvard Medical SchoolBiographyI have been working in the field of chromatin for the last fifteen years, and focusing on sirtuin biology for the last 9 years of my career. I was the first to generate during my post-doctoral research knockout mouse models for all the sirtuins1. When I started my own laboratory, having those mice put me in an ideal position to study their molecular functions. I am currently in the MGH Cancer Center, one of the leading cancer research centers in the US, and since I have been a pioneer in the study of these molecules, I was able to establish successful collaborations with multiple other cancer leaders in this field, a fact that provides me with critical resources for our experiments. My background in chromatin, mammalian systems and molecular biology, and the environment I am currently on, are both critical elements that will likely be determinant in my ability to succeed in our ongoing projects. In the past few years, we have been focusing on the link between epigenetics and metabolism. In particular, we have found that the histone deacetylase SIRT6 is a critical modulator of glucose metabolism, functioning as a tumor suppressor to inhibit metabolic adaptations in cancer cells. We also identified SIRT6 as a critical modulator of DNA repair and cell fate.
Current h-index: 50 Current i10-index: 73.
Eva SegelovDirector of Oncology
Department of MedicineMonash UniversityBiographyProfessor Eva Segelov was appointed as the Professor and Director of Oncology at Monash Health and Monash University in February 2017. She is an Honorary Associate of the NHMRC Clinical Trials Centre, Sydney Medical School and Honorary Professor at Shanghai Jiatong University; previously Associate Professor at the University of New South Wales (UNSW) and Senior Medical Oncologist at St Vincent’s Hospital, Sydney. She is a recognised national and international expert in the fields of gastrointestinal cancer, neuroendocrine tumours and breast cancer, with a 20 year history of management of patients in a multidisciplinary setting. As Deparment Head at Monash Health, she oversees a very large Clinical Trials programme with >260 Oncology trials from Phase 1-IV.
Professor Segelov is an active member of the Australian Gastrointestinal Trials Group (AGITG), where she is a Board Member and Convenor of the Annual Scientific Meeting. She is Chair of the Gastrointestinal Group of the Clinical Oncological Society of Australia (COSA). In 2016 she was nominated as a European Society of Medical Oncology (ESMO) faculty member for the CUP, Endocrine Tumours, and Others group; ESMO 2019 Scientific Sub-Committee member for Neuroendocrine cancer; co-Track Chair of Gastrointestinal Cancer for the 2017 ESMO Asia Annual Scientific Meeting and co-founder of the Commonwealth Neuroendocrine Tumour Society (CommNETS), an international research collaborative. . She is an Associate Editor of Journal of Global Oncology (American Society of Clinical Oncology).
Professor Segelov has led multiple national and international oncology clinical trials, including international investigator-initiated studies. Her research interests relate to translational studies of targeted therapies in defined subpopulations to increase benefit and reduce the toxicity of cancer treatments. She has published over 80 articles, expert reviews, and book chapters and is a frequent invited speaker at national and international conferences. She is a panel member of the 2018 L'Oréal-UNESCO For Women in Science Jury. Professor Segelov has a particular interest in professional development using innovative learning techniques and has developed the Seminal Advances Preceptorship in Cancer courses, now being run through Monash University. She was awarded the UNSW Vice Chancellors Award for Teaching Excellence in 2006.
Professor Segelov heads a colorectal translational research laboratory at Monash University, specializing in interrogating clinical trial biospecimens. The laboratory has wide collaborations with current projects investigating biomarkers for aspirin sensitivity as an adjuvant therapy for colorectal cancer; evaluating a ct-DNA biomarker for colorectal cancer recurrence; investigating the role of dendritic cells in colorectal cancer and examining novel drug therapies.
Department of Radiology and Biomedical ImagingUniversity of California San FranciscoBiographyYoungho Seo, Ph.D., is a Professor in Residence and Director of Nuclear Imaging Physics in the Department of Radiology and Biomedical Imaging, Professor in Residence in the Department of Radiation Oncology at the University of California, San Francisco, and Physicist Faculty Scientist at Lawrence Berkeley National Laboratory. He received his bachelor's degree in Physics from Korea Advanced Institute of Science and Technology (KAIST) where he investigated radiation effects by cosmic ray. He completed a master's degree in Physics at the University of Alabama in Huntsville while focusing on space plasma physics, followed by the second master's degree at the University of California, Los Angeles (UCLA). He finished his PhD in Physics from UCLA with his dissertation on dark matter experiment using dual-phase xenon under the supervision of Professor David B. Cline, followed by postdoctoral training at the same institution for experimental neutrino physics. Dr. Seo joined the UCSF Physics Research Laboratory (PRL) in 2003, and was trained under the supervision of Professor Bruce H. Hasegawa before joining the faculty in 2006.
Dr. Seo leads a group of physicists and engineers working in the field of radionuclide and x-ray imaging instrumentation and physics, and directs the UCSF PRL. His primary research focus is to use quantitative SPECT/CT, PET/CT, and PET/MR molecular imaging tools for a broad range of research areas from small animal imaging using dedicated animal imaging systems and basic instrumentation development to physics analysis of clinical research data. Visit the UCSF PRL webpage to learn more about the current projects. Dr. Seo also directs the preclinical PET/SPECT/CT/Optical imaging core facility at the UCSF Center for Molecular and Functional Imaging at China Basin.
Henri H. VersteegProfessor
Department of Internal MedicineLeiden University Medical CenterBiographyMy main interest is the interplay between tumor cells and blood coagulation. One of the research themes I focus on is how blood clotting promotes tumor growth and cancer metastasis. Specifically, my research team investigates how blood clotting proteins such as tissue factor, factor VII, factor X and thrombin activate receptors on tumor cells to promote cancer progression. In addition, my team has been successful in identifying a role for alternatively spliced clotting factor isoforms in cancer progression.
Another research theme is how the presence of a tumor promotes venous thrombosis in cancer patients. My team investigates how blood components and tumor products cooperate to induce a hypercoagulable state in these patients.
In recent years I have adopted a strategy that includes studying associations between coagulation parameters and clinical outcome in large collections of tumor specimens and to use these associations to set hypotheses. These hypotheses are tested in cell and in vivo models. Based on this work, I was able to publish in general (Proceedings of the National Academy of Science USA) and more specialized journals (Blood, Circulation Research). It resulted in an invitation from Physiological Reviews (IF: 30.176) to write an extensive review on hemostasis. It also resulted in invitations to present State-of-the-art lectures at large international meetings such as the Congress of the International Society of Thrombosis and Hemostasis, and awards ( Novo Nordisk Hemostasis Award, ATVB New Investigator Award, Marie Parijs Award for translational research.
Roberto WeigertSenior Investigator
Laboratory of Cellular and Molecular BiologyNational Institutes of Health BiographyRoberto Weigert, Ph.D. is a Senior investigator in the Laboratory of Cellular and Molecular Biology (LCMB), at the National Cancer Institute (NCI), Center for Cancer Research (CCR) and Chief of the Intracellular Membrane Trafficking Section in the National Institute of Dental and Craniofacial Research (NIDCR), at the National Institutes of Health (NIH). Dr. Weigert got his B.Sc. in chemistry in 1992 at the University of Catania (Italy). He joined the Department of Cell Biology at the Mario Negri Institute, where he studied the mechanism of formation of transport intermediates from the Golgi apparatus. He received his Ph.D. in 2000 from the Open University of London and in 2001 joined the National Heart, Lung and Blood Institute at NIH as a research fellow in the Laboratory of Cell Biology. During his fellowship, Dr. Weigert studied the machinery regulating clathrin-independent endocytic pathways. In 2006, he joined the NIDCR as principal investigator, where he pioneered intravital subcellular microscopy (ISMic) to study various aspects of membrane remodeling during trafficking events in live animals. He was tenured in 2014 and in 2015 he joined the LCMB at NCI.
Division of PathologyUniversity of Texas Southwestern Medical Center BiographyDr. Wenxin Zheng, tenured Professor of Pathology and tenured Professor of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, is also entitled with Mark and Jane Gibson Distinguished Professor in Cancer Research. His main scientific contributions include as follows: 1) Defined and name the precancerous lesion of endometrial serous carcinoma; 2) Lead the research of endometrial serous carcinogenesis; 3) Identified the cell of origin of low-grade ovarian serous carcinoma; 4) Defined the “initial endometriosis” as the earliest recognizable endometriosis in the ovary; 5) Developed “one stop cervical care” clinic for cervical cancer early detection and prevention. Dr. Zheng is a physician scientist, who is an internationally well-recognized gynecologic pathologist and served as a consultant internationally. He has published more than 180 peer reviewed articles in the field.
Ryan C. ChiechiAssociate Professor
Stratingh Institute for ChemistryUniversity of GroningenBiographyRyan Chiechi received his Ph.D. in Chemistry in 2005 under the guidance of Prof. Fred Wudl and Prof. Yang Yang at the University of California, Los Angeles. He focused on developing new pi-conjugated materials using efficient and scalable synthetic routes and used them to fabricate organic light-emitting devices. As a postdoctoral fellow from 2006-2009 at Harvard University with Prof. George M. Whitesides he developed new tools for molecular electronics and nanofabrication, studied charge-transport through arrays of quantum dots and used flames to encode and transmit information. His most notable contribution was the development of eutectic Ga-In as a non-destructive electrode for constructing tunneling junctions from delicate molecular monolayers. In 2009 he joined the Stratingh Institute for Chemistry at the University of Groningen as an Assistant Professor. He won an ERC Starting Grant in 2013 and was promoted to Associate Professor of Organic-Materials Chemistry in 2014. His current research interests are in charge-transport through self-assembled monolayers, unconventional nanofabrication and the design and synthesis of conjugated polymers.
Robert A. FlowersProfessor
Department of ChemistryLehigh UniversityBiographyRobert Flowers is the Danser Distinguished Faculty Chair and Deputy Provost for Faculty Affairs at Lehigh University. He received his B.S. in chemistry from East Stroudsburg University of Pennsylvania in 1986 and his Ph.D. from Lehigh University in 1991. He carried out postdoctoral studies in the Department of Chemistry at Duke University with Professor Ned Arnett. Bob moved to his first independent position as an assistant Professor at the University of Toledo. In 2001, he moved to the Department of Chemistry & Biochemistry at Texas Tech University. In early 2004, he moved to the Department of Chemistry at Lehigh University. Bob’s research group is interested in the mechanistic analysis and development of electron transfer reagents in organic synthesis, applications of proton coupled electron transfer in organic synthesis and organometallic chemistry, and applications of back-scattering interferometry in molecular recognition. He has published over 120 peer-reviewed papers, a book, and five book chapters. He has given over 100 invited US and international lectures at Universities and professional meetings.
Michael A. NashAssistant Professor
Department of ChemistryUniversity of BaselBiographyMichael Nash received a Bachelor of Science in Cybernetics (Systems Biology) with a concentration in Biomedical Systems, graduating Phi Beta Kappa with highest honors from the University of California, Los Angeles in the spring of 2006. He held research internships at the California Institute of Technology NASA Jet Propulsion Lab (Pasadena, CA, USA), the Pacific Northwest National Lab (Richland, WA, USA), and the Biomedical Engineering Department at the University of New South Wales (Sydney, Australia). He earned a dual PhD degree in Bioengineering and Nanotechnology from the University of Washington, Seattle in December 2010. Following Postdoctoral work in Applied Physics at Ludwig-Maximilians-Universität (LMU Munich) from 2011-2012, Michael held a position as non-tenure track Group Leader at LMU from 2013-2016. In 2016, Michael began his current position as a tenure-track Assistant Professor with joint appointments at the University of Basel Department of Chemistry and the ETH Zurich Department of Biosystems Science & Engineering.
Michael's research has been recognized through numerous competitive fellowships and grants, including Fellowships from the U.S. Department of Homeland Security, the U.S. National Science Foundation, the Alexander von Humboldt Foundation, and from The Branco Weiss Society in Science Fellowship. He was awarded a Young Investigator Grant from the Human Frontier Science Program, and in 2016 he was the winner of an ERC Starting Grant. Michael is a senior member of the Swiss Nanoscience Institute and a principal investigator at the Swiss National Center for Competence in Research in Molecular Systems Engineering (NCCR-MSE). His research is in the area of nanobiomaterials and biophysical chemistry, specifically focusing on single-molecule protein mechanical properties, protein and polymer engineering, and the interface between synthetic and biological systems.
Meital RechesAssociate Professor
Institute of Chemistry The Hebrew University of Jerusalem BiographyMeital Reches is an Associate Professor at the Institute of Chemistry and the Center for Nanoscience and Nanotechnology, the Hebrew University of Jerusalem. She received her Ph.D. (with distinction) in 2007 from the Department of Molecular Microbiology and Biotechnology, Tel Aviv University. In 2007-2010, she was an EMBO and a HFSP postdoctoral research fellow at the Chemistry Department, Harvard University. Prof. Reches joined the Institute of Chemistry of the Hebrew University of Jerusalem as a faculty member in October 2010. Her research focuses on understanding, controlling and developing biomolecular self-assembly processes and generating new functional materials. Specifically, her group studies these biomolecular assemblies at the interface with inorganic surfaces.
Edit Y. TshuvaProfessor
Institute of ChemistryThe Hebrew University of JerusalemBiographyBorn in 1975, Edit Tshuva conducted her Ph.D. studies under the supervision of Prof. Moshe Kol at Tel-Aviv University, working on group IV metal complexes as highly active and stereo-selective catalysts for the polymerization of alpha-olefins. After graduating in the year of 2001, she spent two years at The Massachusetts Institute of Technology (MIT) working as a postdoctoral fellow under the supervision of Prof. Stephen J. Lippard on synthetic models for carboxylato-bridged di-iron enzymes. In 2003 she joined the Hebrew University of Jerusalem as a Senior Lecturer, and was promoted to Associate Professor in 2009 and to Full Professor in 2016. Her research group is interested in various topics that relate to synthetic bioinorganic chemistry, applying coordination chemistry techniques in the synthesis and investigation of transition metal complexes that have valuable biological and medicinal applications.
Institute of ChemistryThe Hebrew University of JerusalemBiographyOur research is focused on materials chemistry, nanomaterials and surface chemistry. We are located at the institute of chemistry at The Hebrew University of Jerusalem. The Yerushalmi group research is primarily focused on development and utilization of surface chemistry to modify the chemical and physical properties of materials at the nanoscale.
Fellowships and Awards: Recipient of several prizes including the Krill Prize, Kennedy prize, and the career development award by the Human Frontier Science Program. ERC young scientist research grant for developing large scale architectures with nanometric structured interfaces for charge separation, transport and interception. Young fellow of the Israeli Young Academy, a newly formed organization for the advancement of young scientists and science in Israel, formed by the Israeli Academy of Sciences and Humanities.
Research Interests: Design and synthesis of hybrid nanostructures for photocatalysis, optical applications, energy harvesting. Development of new surface chemistries, the synthesis and surface modification of Hybrid nanostructures, ex-situ doping of nanostructures, nanostructure array assembly, comprehensive characterization of complex nanostructured systems by the application of analytical methods.
Developmental Biology Section
Department of Developmental and Cell BiologyUniversity of California IrvineBiographyKen Cho Ph.D. is a Professor in the Department of Developmental and Cell Biology at the University of California Irvine. He received his undergraduate education at Grinnell College in Iowa, majoring in Chemistry. He received his Ph.D. in 1995 at the University of Pennsylvania where he cloned the first human RNA polymerase gene. During his postdoc at UCLA, he contributed to uncovering the mocleualr nature of Spemann’s organizer. At UC Irvine, he uncovered many critical regualtory mechanisms controlling Nodal and BMP signaling pathways. His current interest are 1) to elucidate the mechanisms controlling endoderm formation by combining experimental and computational approaches, and 2) to understand the preimplantation mammalian development
David C. HayProfessor
MRC Centre for Regenerative MedicineUniversity of EdinburghBiographyDavid Hay is Professor of Tissue Engineering at the University of Edinburgh. David has worked in the field of stem cell biology and differentiation for over fifteen years. David and his team have highlighted the important role that pluripotent stem cells have to play in modelling human liver biology ‘in a dish’ and supporting failing liver function in vivo. The impact of this work has led to a number of peer reviewed publications, regular appearances at high profile conferences and three start-up companies.
Hamed Jafar-NejadAssociate Professor
Department of Molecular & Human GeneticsBaylor College of Medicine BiographyHamed Jafar-Nejad is an Associate Professor in the Department of Molecular & Human Genetics and the Program in Developmental Biology at Baylor College of Medicine. His group is interested in the roles of glycosylation and deglycosylation in the regulation of animal development and human disease pathogenesis. He received his MD degree from Tehran University of Medical Sciences and learned basic molecular biology techniques in a research institute in Iran. He spent one year in the Neuroscience Research Institute at the University of Ottawa, studying the transcriptional regulation of a serotonin receptor implicated in mood disorders with Dr. Paul Albert. He then moved to Houston and started his postdoctoral training in the area of Notch signaling and Drosophila neurogenesis with Dr. Hugo Bellen at Baylor College of Medicine/HHMI. In December 2006, he joined the faculty at the University of Texas Health Science Center at Houston, focusing on a glycosyltransferase called Rumi which he had identified in Drosophila as a key regulator of the Notch signaling pathway. In 2012, he was recruited back to the Department of Molecular & Human Genetics at Baylor, where his group continues their work on the role of glycosylation in animal development and human disease. Hamed’s lab has established a mouse model for a rare disease called Alagille syndrome and has identified Rumi (Poglut1) as a dominant genetic suppressor of the Alagille biliary phenotypes in the mouse. The Jafar-Nejad group is also using Drosophila and mammalian cell culture assays to understand the role of a deglycosylation enzyme called N-glycanase 1 (NGLY1) in animal development and BMP signaling, in hopes of shedding light on the pathophysiology of NGLY1 deficiency in human patients and identifying drug targets for this disease.
Philip JordanAssociate Professor
Biochemistry and Molecular Biology DepartmentJohns Hopkins UniversityBiographyPhilip Jordan is an Associate Professor in the Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health in Baltimore, Maryland. He received his undergraduate with honors degree from Flinders University of South Australia, and a Ph.D. from the University of Edinburgh, UK. During Dr. Jordan’s training he developed a keen focus on research that encompasses maintenance of genome integrity and cell cycle progression. As a post-doctoral fellow (2007 to 2010) in Eva Hoffman’s lab at the Genome Damage and Stability Center, University of Sussex, UK, he studied the roles of structural maintenance of chromosome complexes (SMC) and cell cycle kinases (Aurora and Polo-like kinases) using budding yeast as a model organism. He then moved to Mary Ann Handel’s lab at the Jackson Laboratory, Maine, USA, as a Fulbright Distinguished Scholar. Here he learned to use mouse as a model organism and continued his research on SMC complexes and cell cycle kinases. Dr. Jordan received a K99 Pathway to Independence Award from the NIH, and in 2013 he was recruited as faculty at Johns Hopkins University. His research program encompasses using budding yeast, mice, as well as mouse and human stem cells to discover the functions of SMC complexes and cell cycle kinases that ensure genome stability.
Department of Cell, Developmental and Integrative BiologyUniversity of Alabama at BirminghamBiographyDr. Michael Miller received a Ph.D. from the University of California, Irvine working in Dr. Rob Steele’s lab. After graduating, Dr. Miller completed a postdoctoral fellowship in Dr. David Greenstein’s lab at Vanderbilt University. Dr. Miller is currently Professor of Cell, Developmental and Integrative Biology at the University of Alabama at Birmingham School of Medicine. His lab uses Caenorhabditis elegans as a simple model for investigating molecular mechanisms by which cells coordinate fundamental behaviors, such as migration, cell cycle progression, and differentiation. A key experimental paradigm is fertilization. In C. elegans, oocytes and sperm secrete extracellular signaling molecules derived from proteins and fats to control oocyte meiotic progression and sperm migration, respectively. An overarching theme of Dr. Miller’s research program is to delineate the signaling mechanisms critical for fertilization and to investigate their evolutionary origins. These studies are providing insight into animal development and reproduction, as well as diseases such as amyotrophic lateral sclerosis and cancer.
Margaret Saha Professor
Department of BiologyCollege of William and MaryBiographyDr. Margaret Saha is a Chancellor Professor of Biology at the College of William and Mary with affiliate appointments in the Neuroscience Program and the Department of Applied Science. She completed a Ph.D in the History of Science from Michigan State University and a Ph.D. in Developmental Biology from the University of Virginia. She joined the faculty of the Biology Department at the College of William and Mary in 1993 where she has taught Developmental Biology, Introductory Biology, Phage Lab, Freshmen Genomics Lab, as well as upper level seminars in bioinformatics and developmental neurobiology. Dr. Saha has had a longstanding interest in developing novel approaches to engage and retain students in the sciences, particularly members of underrepresented minorities, and has been the Program Director for five consecutive Howard Hughes Medical Institute Science Education grants to the College of William and Mary and has also served as a member of the Executive Board for Beckman Scholars Program. As the mother of five children, she has been actively involved in disseminating appropriate research into the high school classroom and routinely offers summer “update” courses for local teachers to keep them abreast of topics and techniques in contemporary life science. Her research focuses on understanding the molecular genetic mechanisms underlying early embryonic plasticity of the developing nervous system, specifically the processes by which embryos respond to and recover from perturbations—genetic, physical, and environmental. She has mentored over one hundred undergraduates in her research laboratory with many students serving as co-authors on peer-reviewed papers and presenting their research at national meetings. Her research has been funded by grants from the National Science Foundation and the National Institutes of Health. Various awards include a Presidential Faculty Fellowship from the National Science Foundation and a Virginia Outstanding Faculty Award.
Leonard I. ZonProfessor
Department of Stem Cell and Regenerative BiologyHarvard Stem Cell InstituteBiographyDr. Leonard I. Zon is the Grousbeck Professor of Pediatric Medicine at Harvard Medical School, Investigator at Howard Hughes Medical Institute, and Director of the Stem Cell Program, Children’s Hospital Boston. He is founder and former president of the International Society for Stem Cell Research and chair of the Executive Committee of the recently formed Harvard Stem Cell Institute (HSCI). In 2005, he completed a term as President of the American Society for Clinical Investigation. In that same year, Dr. Zon was elected to the Institute of Medicine of the National Academies. In 2008, Dr. Zon was elected to the American Academy of Arts & Sciences and in 2010, Dr. Zon was awarded the E. Donnall Thomas Lecture and Prize from American Society of Hematology. In 2013, Dr. Zon received the ISEH Donald Metcalf Lecture Award.
Dr. Zon received a B.S. degree in chemistry and natural sciences from Muhlenberg College and an M.D. degree from Jefferson Medical College. He subsequently did an internal medicine residency at New England Deaconess Hospital and a fellowship in medical oncology at Dana-Farber Cancer Institute. His postdoctoral research was in the laboratory of Stuart Orkin.
Dr. Zon is internationally recognized for his pioneering work in the fields of stem cell biology and cancer genetics. He has been the pre-eminent figure in establishing the zebrafish as an invaluable genetic model for the study of the blood and hematopoietic development. The laboratory focuses on the developmental biology of hematopoiesis and cancer. They have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. They also have undertaken chemical genetic approach to blood development and have found that prostaglandins upregulates blood stem cells. This has led to a clinical trial to improve engraftment for patients receiving cord blood transplants. They recently developed suppressor screening genetics and found that transcriptional elongation regulates blood cell fate. The laboratory has also developed zebrafish models of cancer. They have generated a melanoma model in the zebrafish system using transgenics. Transgenic fish get nevi, and in a combination with a p53 mutant fish develop melanomas. They recently found a histone methyltransferase that can accelerate melanoma, and discovered a small molecule that blocks transcription elongation and suppresses melanoma growth.
Sergey BorisenkoGroup Leader
Synchrotron MethodsLeibniz Institute for Solid State and Materials Research (IFW) - DresdenBiographyI completed my Ph.D. in Solid State Physics from Moscow Institute of Physics and Technology and Institute for Metal Physics, Kyiv, Ukraine. After that, I started as a Postdoc in IFW-Dresden, working on high-temperature superconductivity. I am an experimentalist studying electronic structure of different materials by means of different modifications of angle-resolved photoemission spectroscopy (ARPES). Now I am running a "Synchrotron Methods" group in IFW and my current interests are superconductivity and topological matter.
Seth B. DarlingDirector
Institute for Molecular EngineeringArgonne National LaboratoryBiographySeth B. Darling is the Director of the Institute for Molecular Engineering at Argonne National Laboratory, which is a joint institute with the University of Chicago. After receiving his Ph.D. from the University of Chicago in Physical Chemistry, he joined Argonne National Laboratory as the Glenn Seaborg Distinguished Postdoctoral Fellow in the Materials Science Division. Following his postdoc, Darling became a staff scientist in the Center for Nanoscale Materials at Argonne. His group’s research centers around molecular engineering with a particular emphasis on advanced materials for water treatment and renewable energy. He has published over 100 scientific articles, holds several patents, is a co-author of a popular book intended for general audiences debunking climate skeptic myths, and lectures widely on topics related to energy, water, and climate.
Department of Energy and Chemical EngineeringHarbin Institute of TechnologyBiographyYang Gan obtained his BE from Sichuan University (1995), and both his ME (1998) and PhD (2001) from Institute of Metal Research of Chinese Academy of Sciences. Before joining Harbin Institute of Technology (HIT) in 2006, he took postdoctoral and visiting scholar positions at the University of Science and Technology Beijing, Newcastle University and Melbourne University. His research interests are surface physical chemistry and surface engineering. He contributed 60+ publications and patents. He won the Frans Habraken Best Paper Award (2013) and the HIT Teaching Excellence Award (2014). He was elected as a Fellow of the Royal Society of Chemistry (FRSC) in 2015.
Michel GodinAssociate Professor
Department of PhysicsUniversity of OttawaBiographyProfessor Godin’s research seeks the development of microfluidic and nanofluidic technologies for biomedical applications.
While we have seen great advances in chemical/biological sensing, health screening, and diagnostics in recent years, there are still some great challenges that remain to be addressed. The relevant antigen (target) concentration for various disease states often challenges the limits of detection of current technologies. The complexity of real-world samples such as blood, urine, saliva or food makes the detection of a specific disease biomarker or pathogen challenging, requiring complex sample preparation procedures. Also, the success of a sensing technology will be impacted by cost and ease of deployment in non-standard settings such in third world areas or even for bedside diagnostics.
We seek to address these issues from four fronts:
1)Biosensing: Development of novel assays and detection/characterization technologies
2)Lab-on-a-Chip: Implementation of sample manipulation, separation and concentration platforms
3)Science: Establishing a fundamental understanding of the science relevant to each sensing platforms
4)Technology: Providing new quantitative measurement capabilities for conducting basic research in biology, chemistry and physics
Li (Emily) LiuAssociate Professor
Department of Mechanical,Aerospace and Nuclear EngineeringRensselaer Polytechnic InstituteBiographyDr. Liu is an Associate Professor of Nuclear Engineering and Engineering Physics in the Department of Mechanical, Aerospace, and Nuclear Engineering at Rensselaer Polytechnic Institute (RPI). Dr. Liu earned her PhD from Massachusetts Institute of Technology and her B.S. from Peking University. As a Physicist and Nuclear Engineer by training, Liu’s research is focused on solving high impact problems associated with energy and the environment through fundamental investigations into the structure-function relationships of materials. For this purpose she is developing a variety of experimental and computational tools based on neutron, X-ray, and light scattering as well as molecular dynamics (MD) and phase field simulations.
Moreover, Professor Liu’s science based communication/societal research extends into many areas. Collaborating with psychologists, she explores the technical and social aspects of a nuclear/radiological event, especially focusing on the emergency management and decision technologies to support preparedness, response, and recovery. Collaborating with financial engineers, she builds economic analysis to measure sustainability of advanced hybrid energy systems and develops new optimization economic/technical model for nuclear fuel cycle. Collaborating with course developers, she discovers innovations and exciting strategies for her courses.
Arash Mafi is an Associate Professor of Physics and Astronomy at the University of New Mexico (UNM) and a Fellow of the Optical Society. He is also the Director of the Center for High Technology Materials (CHTM) at UNM. Mafi received his undergraduate degree in Physics from Sharif University of Technology, and his Master's and Ph.D. degrees in Physics from The Ohio State University. Following his postdoctoral appointments at the University of Arizona in Physics and The Optical Sciences Center, he joined Corning Inc. as a Senior Research Scientist working on optical fibers and liquid crystal displays. He moved to the University of Wisconsin-Milwaukee in 2008, where he was an Associate Professor of Electrical Engineering and Computer Science, before joining the University of New Mexico in 2014. Mafi served as the General Chair of the Optical Science and Engineering (OSE) Graduate Program in the 2015-2016 academic year. His research interests include quantum and nonlinear behavior of optical waveguides, light propagation in disordered media, and fiber lasers.
Department of PhysicsUniversity of AlbertaBiographySince obtaining his Ph.D. in 1997, Dr. Meldrum has been working extensively on materials for nanotechnology and optics. Now a full professor at the University of Alberta, he has more than 160 refereed publications in physics, chemistry, and optics journals including Advanced Materials, Nature, Nanoletters, Physical Review Letters, Optics Express, and many others, and he holds two US patents. Dr. Meldrum has numerous invited presentations at conferences, both in Canada and internationally, has organized several major national and international research symposia. He has a citation H-index of 39 in condensed matter physics and optics. In addition to research awards such as the Petro-Canada “Young Innovator Award” in 2003 and the Mineralogical Association of Canada’s “Young Scientist Medal” in 2005, he has won numerous teaching awards from the students, faculty, and university, including the Rutherford Award for Excellence in Undergraduate Teaching, which is the highest teaching award at the University of Alberta. In 2017 he was the first Graduate Student Mentoring Award winner from the Department of Physics. Dr. Meldrum currently holds a Vargo Teaching Chair and runs an optics and lasers lab and a transmission electron microscope lab at the University of Alberta. In 2017 Dr. Meldrum started a spin-off company, Grayflare Inc, which develops optical devices and materials.
Michel Pioro-LadrièreAssociate Professor
Departement of PhysicsUniversité de SherbrookeBiographyMichel Pioro-Ladrière is an expert in spin qubit technology and deputy director of Institut Quantique at Université de Sherbrooke. He received a Ph.D. (2005) in experimental Physics from Université de Sherbrooke, in partnership with the National Research Council of Canada (NRC), winning the NRC Exceptional Accomplishment Award in the process. He was then welcomed as a postdoctoral fellow at the Japan Science and Technology Agency from 2005 to 2009, where he pioneered a micromagnet approach to realize efficient single spin rotations, which is now used worldwide in spin-based quantum information processing research. He was recruited back in 2009 by Université de Sherbrooke, in collaboration with the Canadian Institute for Advanced Research (CIFAR), to jumpstart the first research program in Canada that utilize components found in today’s microchips to ultimately create a quantum computer. Michel Pioro-Ladrière is the author of 50 peer-reviewed articles and 3 patents. Prof. Pioro-Ladrière is a CIFAR fellow in the Quantum Information Science program, and member of Unité Mixte Internationale – Laboratoire Nanotechnologies & Nanosystèmes (CNRS, France).
Sandipan PramanikAssociate Professor
Department of Electrical and Computer EngineeringUniversity of AlbertaBiographySandipan Pramanik received M.Sc. (2003) and Ph.D. (2006) degrees, both in Electrical and Computer Engineering, from Virginia Commonwealth University, Richmond, Virginia, USA. Currently he is an Associate Professor in the Department of Electrical and Computer Engineering, University of Alberta, Canada. His research includes several areas of nanoelectronics such as graphene, carbon nanotubes, organic and chiral molecules and semiconductors and behavior of charge carrier spins in such materials.
Michael VershininAssistant Professor
Department of Physics & AstronomyUniversity of UtahBiographyDr. Michael Vershinin is a faculty member of the Department of Physics & Astronomy and a member of the Center for Cell and Genome Science at the University of Utah. Dr. Vershinin received his Ph.D. in Physics from University of Illinois at Urbana-Champaign. He was a postdoctoral fellow in the laboratory of Dr. Steven Gross at UC Irvine. Dr. Vershinin's research focuses on the cytoskeleton and associated processes.
Department of Mechanical EngineeringIowa State UniversityBiographyDr. Xinwei Wang is a full professor at Iowa State University (http://web.me.iastate.edu/wang). He obtained his Ph.D. from the School of Mechanical Engineering, Purdue University in 2001, and had his M.S. (1996) and B.S. (1994) from the University of Science and Technology of China. Over the past 17 years, he has led his laboratory to develop various novel technologies for micro/nanoscale thermal characterization, study ultrafast-laser material interaction, investigate light-structure coupling, and probe energy transport in various materials down the sub-nm scale. His current work focuses on energy transport in macromolecules, 2D atomic layer materials, atomic scale interface phonon energy transport, and in-situ probing and characterization of fuels in nuclear reactors. He has published 133 papers in highly-visible journals. He received the inaugural Viskanta Fellow Award of Purdue University in recognition of his pioneering and independent work in thermal sciences. He is the recipient of the 2014 mid-career award for research of Iowa State University. He is the Fellow of American Society of Mechanical Engineers (ASME) and Associate Fellow of American Institute of Aeronautics and Astronautics (AIAA).
Axel MithoferGroup Leader
Department of Bioorganic Chemistry Max Plank Institute for Chemical EcologyBiographyDr. Axel Mithofer studied Biology and got his PhD in Botany from the Ruhr-University Bochum, Germany. He is heading the project group ‘Plant Defense Physiology’ at the Bioorganic Chemistry Department of the Max Planck Institute for Chemical Ecology in Jena, Germany. He is also Associate Professor at the Friedrich Schiller University, Faculty of Biological Sciences, in Jena. His research interests are in the field of interactions of plants with other organisms, microbes as well as herbivores His main focus lies on signal perception, signal transduction, and defense responses. In addition, a second field of interest is the biology of the carnivorous syndrome in plants.
Lucio MontecchioAssociate Professor
Forest Pathology and Amenities Trees PathologyUniversity of PadovaBiographyLucio Montecchio earned his M.Sc. degree in Forest Sciences from the University of Padova. He’s an Associate Professor of both forest pathology and amenity trees pathology at the same University. He qualified for Full Professorship in 2017.
He is the author of more than 120 technical and scientific papers and book chapters, and four patents. His research focus on the biology, epidemiology and pathogenicity of fungal parasites in forest and ornamental trees, and on the dynamics of the mutualistic fungal communities associated with trees health.
Through the University spin-off De Rebus Plantarum, his research focus also on environment-friendly approaches on diseases control by means of trunk injection treatments. He’s involved in internationally funded researches and actions, and holds advisory positions on both national and international levels.
Mileva RadonjicAssociate Professor
Sustainable Energy and Environmental ResearchLouisiana State University BiographyMileva Radonjic, Ph.D. is an Associate Professor, with the background in geology and materials science. She is currently in the process of moving to Oklahoma State University, Chemical Engineering Department, after 10yrs at LSU. She is the project director of the NAS GRP $2,6M grant, that is developing novel materials for plugging and abandonment of wells in the Offshore conditions, such as the Gulf of Mexico. In addition to strong research focus on sustainable wellbore construction, interdisciplinary approach to global societal issues, such as climate change and limitation of environmental impact of fossil fuel production, she is an advocate for the academic freedom, integrity and diversity. She is equally passionate about research based teaching, at both graduate and undergraduate level, and an avid supporter of equity of women and minorities in STEM disciplines.
Igor V. SharakhovAssociate Professor
Department of EntomologyVirginia Tech BiographyIgor V. Sharakhov serves as a Professor in the Department of Entomology at Virginia Polytechnic and State University (Virginia Tech) in the USA. He was appointed to the Virginia Tech faculty as an Assistant Professor in 2004. Dr. Sharakhov works in the area of genomics and evolutionary cytogenetics of mosquitoes – vectors of human infectious diseases. Dr. Sharakhov made contributions to understanding the patterns and mechanisms of the genome evolution in mosquitoes, which could be useful for development of more effective mosquito control. Some of his specific contributions and achievements include mapped genome assemblies for Anopheline mosquitoes, important vectors of malaria; identification of heterochromatic genes and regulatory piRNAs, which has improved our understanding of the “dark matter” of the mosquito genome and opened a new venue for the discovery of genetic determinants of the chromosome organization; and new insights into the role of chromosomal inversions in adaptation and evolution of malaria mosquitoes. Dr. Sharakhov's research is funded by grants from the National Science Foundation and the National Institutes of Health.
Yinjie TangAssociate Professor
School of Engineering and Applied ScienceWashington University in St. LouisBiographyDr. Tang has expertise in environmental microbiology, kinetic modeling, and metabolic flux analysis. Dr. Tang did his Ph.D. in Chemical Engineering at the University of Washington (with Dr. Barbara Krieger-Brockett). During his postdoctoral period (2004~2008), he worked on genomics projects at Lawrence Berkeley National Laboratory (with Dr. Jay Keasling). He has worked at Washington University since 2008, where his research focuses on characterizing and engineering nonmodel microorganisms for bio-manufacturing.
Michael BergerAssociate Director
Marie-Josee & Henry R. Kravis Center for Molecular OncologyMemorial Sloan Kettering Cancer CenterBiographyMichael Berger, PhD, is an Associate Director of the Marie-Josée and Henry R. Kravis Center for Molecular Oncology at Memorial Sloan Kettering Cancer Center, a multidisciplinary initiative to promote precision oncology through genomic analysis to guide the diagnosis and treatment of cancer patients. He is also an Associate Attending Geneticist in the Department of Pathology with expertise in cancer genomics, computational biology, and high-throughput DNA sequencing technology. His laboratory is developing experimental and computational methods to characterize the genetic makeup of individual cancers and identify genomic biomarkers of drug response and resistance. As Scientific Director of Clinical NGS in the Molecular Diagnostics Service, he oversees the development and bioinformatics associated with clinical sequencing assays, and he helped lead the implementation and validation of a robust molecular profiling platform (MSK-IMPACT) and accompanying analytical framework for use in real-time patient management. He received his Bachelor’s Degree in Physics from Princeton University and his Ph.D. in Biophysics from Harvard University.
Eric Brian Kmiec Director
Gene Editing InstituteHelen F. Graham Cancer Center & Research InstituteBiographyDr. Eric B. Kmiec is the Founder and Director of the Gene Editing Institute at the Helen F. Graham Cancer Center & Research Institute at Christiana Care Health System. His translational research focuses on gene editing, specifically using CRISPR, to catalyze genetic reengineering. Dr. Kmiec holds faculty appointments at the University of Delaware, the Wistar Institute and Georgetown University. His laboratory has been continuously supported by the National Institute of Health grants with other funding from the National Science Foundation, the NIST-BIRD Foundation, and the American Cancer Society, among many others. Dr. Kmiec has been the primary thesis advisor for 18 PhD doctoral students as a full, tenured Professor at the University of Delaware and is the founder of two biotechnology companies. He serves on five editorial boards, has authored 160 peer-reviewed publications, as primary or senior author, and edited several books on gene therapy. Dr. Kmiec has 15 issued patents and has received service medals and awards, including the Genome Canada Lectureship, the Proudford Research Award and the PICC Life Science Innovator Award in 2018. Dr. Kmiec was named an Honorary Commander at Dover Air Force Base and an Eminent Scholar at Marshall University.
Departments of Medicine (Oncology) and GeneticsAlbert Einstein College of MedicineBiographySridhar Mani M.D. is currently a Professor of Medicine, Genetics and Molecular Pharmacology at the Albert Einstein College of Medicine, Bronx, NY. Dr. Mani's (a.k.a Sridhar) focus is to develop detailed efforts on the role of microbes and microbial metabolites in dictating host physiology and immunity. Additionally, Sridhar's work also focuses on the study (molecular and translational biology) of orphan nuclear receptors as it relates to drug metabolism and immunity. The Mani Lab has been continuously funded by the National Institutes of Health (NIH) and more recently by the US Department of Defense (DoD).
Orphan nuclear receptors (those that lack a well defined physiologic ligand) control nearly every major physiologic and biochemical process in eukaryotes - cell metabolism (e.g., cholesterol, energy, bile acids), xenobiotic detoxification, cell differentiation (e.g., gastrulation, retinal development), circadian rhythm, and cancer cell growth and apoptosis (e.g., NURR77). Of these receptors, the steroid and xenobiotic receptor or pregnane X receptor (SXR or PXR) is a key regulator of genes encoding drug metabolizing and transport proteins. In addition, SXR has been implicated in cancer drug resistance, carcinogenesis, innate immunity, infection control and pathophysiologic states like osteomalacia. Our NIH-funded laboratory focuses on defining the role of SXR and other orphans by using novel and dynamic in vitro and in vivo models of human pathophysiology in (i) xenobiotic metabolism and pharmacology; (ii) carcinogenesis, organogenesis and anticancer drug resistance and (iii) innate immunity.
Recently, our laboratory has directed interests in the mammalian microbiome (bacteria, viruses, fungi). We have discovered a novel link between the microbial metabolome and orphan nuclear receptor, SXR/PXR in the intestines (Immunity, 2014). Further work in the laboratory is focussed on defining how the microbial environment shapes health and disease. The overall theme of our research going forward is to understand the mechanistic basis of host immune system and its regulation by gut microbiota through their secretion of small molecule metabolites and/or proteins. The techniques and methodologies (protocols) used in our laboratory involve use and generation of genetic mouse models, study of bacterial phenotypes using classical and translational microbiology, DNA/RNA sequencing, cell, molecular and proteomic technologies. It is hoped that through such investigation we will discover new therapeutic leads (drug discovery) for diseases such as inflammatory bowel disease and colon cancer (translational research).
Corey NislowAssociate Professor
Faculty of Pharmaceutical SciencesUniversity of British ColumbiaBiographyDr. Nislow completed a Bachelor of Arts in developmental biology at New College (Sarasota, Florida) and a Doctor of Philosophy in cell and molecular biology at the University of Colorado (Boulder, Colorado). Dr. Corey Nislow is an Associate Professor in the Faculty of Pharmaceutical Sciences, a Co-Founder and Director of the Sequencing + Bioinformatics Consortium, and an Advisor to the Advanced Research Computing group all at the University of British Columbia, as well as a Co-Founder of Genetic Networks LLC. Formerly, he served as group leader in two biotechnology companies (MJ Research and Cytokinetics Inc., in the San Francisco Bay Area) and as a Senior Genome Scientist at Stanford University. He was also an Associate Professor at the University of Toronto and Director of the Donnelly Sequencing Centre.
Dr. Nislow is a cell biologist and geneticist whose lab employs genomics and develops biotechnology tools to address both fundamental and applied biological questions using technologies such as parallel genome-wide chemical genomic screens, high throughput cell-based screens, and next generation sequencing. His research program has developed and deployed an array of chemical genomic tools for systems biology including protocols to perform genome wide screens on the International Space Station to which he has launched 4 science missions. He is the lead researcher for the Genomics for Precision Drug Therapy in the Community Pharmacy a first-in-Canada trial that empowers patients to directly access their genome data for medication management. Dr. Nislow has been involved in a few notable scientific projects; cloning the first human mitotic kinesin, identifying the founding member of the SET family of chromatin modifiers, and produced the first comprehensive genome-wide map of nucleosome occupancy in an organism.
Dr. Nislow is an accomplished academic with 170 peer-reviewed publications and 6 patents, as well as an enthusiastic instructor that enjoys teaching all aspects of biotechnology, genomics, and drug discovery for students and trainees.
Immunology and Infection Section
Christian BranderAssociate Professor
Host Genetics and Cellular ImmunityIrsiCaixa Institut de Recerca de la SidaBiographyChristian Brander graduated from the University of Bern in 1994 with a PhD in Immunology studying exogenous antigen re-presentation on HLA class I molecules and T-cell hyper-reactivity reactions to Penicillin. He then spent 13 years at Harvard University focusing on cellular immunity to viral infections and the impact that host genetics have on this immune response. He joined ICREA in 2008 with an appointment at the IrsiCaixa AIDS Research Institute to continue his work on host genetics and the cellular immunity to viral infections, including HIV, HCV and herpesviruses such as KSHV and EBV. He is the curator of the Los Alamos HIV Immunology database and the scientific director of the HIVACAT program, a project for the development of effective preventive and therapeutic HIV vaccines.
Fabienne Brilot-TurvilleAssociate Professor
Brain and Mind CenterUniversity of SydneyBiographyProf. Fabienne Brilot performed her Ph.D. in Belgium and at the JD Gladstone Institutes, UCSF, USA. She then became postdoctoral fellow under the mentorship of Professor Christian Munz (currently located at the University of Zurich, Switzerland) at the Browne Center for Immunology and Immune Diseases headed by late Professor Ralph Steinman (Nobel Prize for Medicine 2011) at the Rockefeller University, USA. She was recruited at the Children’s Hospital at Westmead in Sydney in 2007 where she started the Brain Autoimmunity group. Fabienne is currently Principal Research Fellow at the University of Sydney, and her research focuses on immune-mediated brain disorders such demyelinating disorders and movement and psychiatric disorders. Her group aims to discover biomarkers and explores the autoimmune response in patients to improve their diagnosis and treatment.
Institute of Microbiology/CHUVUniversity of LausanneBiographyProf. Gilbert Greub is the current Director of the Institute of Microbiology of the University Hospital of Lausanne (Switzerland). He is also Chef de Service and Head of medical microbiology at the University Hospital of Lausanne. His activities mainly include research, teaching, & diagnostics as a microbiologist, as well as patient care as an infectious diseases specialist.
Born in 1967, he studied medicine at the University of Geneva. Then he did a M.D. degree at the University of Lausanne and a Ph.D. at the University of Aix-Marseille (France). He specialized as FMH in internal medicine, FMH in infectious diseases, and FAMH in microbiology. Since 2004, he is leading the Center for Research on Intracellular Bacteria, a research center mainly dedicated to the study of chlamydia and chlamydia-related bacteria. Among others, his group recently successfully studied the division of these bacteria (Jacquier et al Nature Communication 2014; Frandi et al Nature Communication 2014; Jacquier et al Biol Chem 2015), identifying possible new future drug targets. His group also developed some ELISA-based diagnostic tests (Lienard et al 2014; Kebbi et al 2012, Greub et al 2009). For all this research, G Greub received several prices including the European ESCMID young investigator award (2006), the Viollier award (2010), the Leenaards award (2011), the Naef Price (2010), and the Fond Carlo - Philanthropia price from Lombard-Odier foundation (2016). Associate Editor in three Journals, he is also the current president of the Swiss Society of Microbiology and the chairman of the International subcommittee for chlamydial taxonomy.
Bryan HurleyAssistant Professor
Department of PediatricsMassachusetts General HospitalBiographyI am an Assistant Professor of Pediatrics at Harvard Medical School and a Principal Investigator within the Mucosal Immunology & Biology Research Center at Massachusetts General Hospital. I manage an independently funded research program focused on understanding cellular and molecular mechanisms that facilitate inflammatory and toxic breach of protective mucosal barriers. A primary area of focus for our team involves investigating how neutrophils migrate across mucosal barriers following infection or in the context of inflammatory disease. I received a Ph.D. in Immunology from Tufts University Sackler School of Graduate Biomedical Sciences in Boston, MA.
Biology of Infection UnitInstitut PasteurBiographyMarc Lecuit, M.D., Ph.D., is a microbiologist and an infectious diseases physician. He is the Director of the Biology of Infection Unit at Institut Pasteur and Inserm, and the Head of the National Reference Centre and WHO Collaborating Centre Listeria.
.He is a Professor at the Paris Descartes University and Deputy Head of the Department of Infectious Diseases and Tropical Medicine at the Necker-Enfants Malades University Hospital. Research in the Lecuit Lab (www.pasteur.fr/research/biu) is focused on understanding the host and microbial mechanisms underlying host invasion and within-host dissemination. The pathogens studied include bacteria such as Listeria monocytogenes and Group B streptococcus, and emerging viruses such as chikungunya and Zika viruses.
Reza ArdehaliAssociate Professor
Division of CardiologyUniversity of California Los AngelesBiographyReza Ardehali, M.D., Ph.D. is a clinician-scientist who studies the molecular mechanisms involved in heart development and disease. Of particular interest to Dr. Ardehali is the intrinsic signaling that triggers cardiac regeneration early in life, molecular events that regulate developmental decisions instructing cardiac progenitors to adopt a specific cell fate, and delivery approaches of cardiovascular progenitors into an injured heart. His laboratory also uses pluripotent stem cells for disease modeling, as well as for regenerative purposes. They have initiated pre-clinical studies of transplantation of human embryonic stem cell-derived cardiomyocytes in large animal myocardial infarction models. He is a practicing cardiologist, specializing in advanced heart failure and heart transplantation.
Gerald BrandacherAssociate Professor
Department of Plastic and Reconstructive SurgeryJohns Hopkins UniversityBiographyDr. Gerald Brandacher is Scientific Director of the Johns Hopkins Reconstructive Transplantation program. He is also an Associate Professor of Surgery in the Departments of Surgery and Plastic and Reconstructive Surgery at Johns Hopkins University School of Medicine.
Prior to joining Johns Hopkins in 2010, Dr. Brandacher was a key member of the hand transplant programs in Innsbruck, Austria and at the University of Pittsburgh. As scientific director of the program at UPMC he was instrumental in designing a novel cell-based immunomodulatory treatment protocol for VCA and was also part of the team performing the first bilateral hand transplant and first forearm transplant in the US. His main scientific interests are donor-specific immune tolerance and immunomonitoring strategies.
Dr. Brandacher received his medical degree summa cum laude from Leopold Franzens University, Innsbruck, School of Medicine, and completed further surgical training at the Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, at Innsbruck Medical University. He is the recipient of many prestigious national and international awards related to his work in reconstructive transplantation including The Young Investigator Awards of the American Society of Transplantation and the European Society of Organ Transplantation, The Young Innovator Award of the American Society of Transplantation and the Excellence in Research Award of the American College of Surgeons. Dr. Brandacher has mentored 60 pre- and post-doctoral researches over the past 15 years, and has authored more than 195 peer reviewed papers,27 book chapters, and has edited two textbooks on hand transplantation. In 2014, he co-founded the journal Vascularized Composite Allotransplantation (VCA), and currently serves as its Editor-in-Chief. Dr. Brandacher is the principal investigator of multiple major federal research grants totaling >10M USD in funding on projects related to upper extremity transplantation, cell-based immune modulation, and tolerance induction. He has given over 130 invited lectures and has been a visiting professor around the world and at leading American medical institutions.
Dr. Brandacher has served as the President of the Austrian Society of Surgical Research (2008-2009) and as Chair of the American Society of Transplantation (AST) Vascular Composite Allotransplantation Advisory Council (2014-15). He was elected as Chair of the Vascularized Composite Allotransplantation Committee of the European Society of Organ Transplantation (ESOT) in 2015, and is a Founding Member of the American Society of Reconstructive Transplantation (ASRT), for which he currently serves as the President Elect. He is a Member at Large to the OPTN/UNOS Vascularized Composite Allograft Transplantation (VCA) Committee. In 2015 he was selected as a “Fellow of the American Society of Transplantation”.
The Malawi Liverpool Wellcome Trust Clinical Research ProgrammeQueen Elizabeth Central HospitalBiographyStephen Gordon is Director of the Malawi Liverpool Wellcome Clinical Research Programme (MLW). This programme hosts over 100 clinical studies, 550 staff, 120 postgraduate students and is the largest research institute in Malawi. Stephen has conducted clinical and translational research since 1993 – his research in pulmonary disease in Africa began in 1996. His initial research focus was on HIV-associated macrophage functional defects, specifically against Streptococcus pneumoniae. He subsequently expanded his interest to a wider appreciation of pulmonary mucosal immunology, including the effect of household air pollution on pulmonary defence and the potential for mucosal vaccination to prevent infection. At the Liverpool School of Tropical Medicine, where he worked for 10 years before moving back to Malawi in 2015, Stephen established a controlled human infection model of pneumococcal carriage in order to determine the correlates of protection from carriage and the immunising effects of carriage on the respiratory tract.
Thierry LeveillardResearch Director
Department of GeneticsInstitut de la VisionBiographyDr. Leveillard identified the truncated thioredoxin-like protein Rod-derived Cone Viability Factor (RdCVF), a rod-secreted protein encoded by the nucleoredoxin-like 1 (NXNL1) gene whose depletion in retinitis pigmentosa leads to cone cell death. His group elucidates the mechanism of action of RdCVF and demonstrated that RdCVF participates in a novel metabolic and redox signaling involving RdCVF and the thioredoxin RdCVFL, the second product of the NXNL1 gene. NXNL1 is a possible treatment for retinitis pigmentosa independent of causative mutations.
Eric C. LiaoDirector
Cleft and Craniofacial CenterMassachusetts General HospitalBiographyDr. Liao is an Associate Professor in Surgery and Genetics, and serves as the Director of Cleft and Craniofacial Center at Mass General Hospital for Children. He also directs research as Principal Faculty of the Harvard Stem Cell Institute at the Center for Regenerative Medicine. His research program is focused on the genetic regulation of craniofacial development, with particular emphasis in translation of human genetics to mechanistic understanding of gene function. His laboratory has developed various models to address functional genomics questions, using induced pluripotent stem cells (iPSC) and zebrafish systems to complement more traditional murine models.
Dr. Liao is unique in combining his expertise in treatment of patients with complex craniofacial anomalies with complementary frontier fundamental research, with the goal of improving patient outcomes. Dr. Liao wants to know everything possible in craniofacial anomalies, with vertical analysis of the underlying biological basis and how this impacts patient outcomes.
Dr. Liao graduated from Stanford University, Harvard Medical School / M.I.T. (MD, PhD), and trained in Harvard Plastic Surgery Residency. Dr. Liao's clinical and academic excellence have earned numerous prestigious awards: American Surgical Association Fellowship, Basil O'Connor Scholarship, MGH Cancer Center 100 Honoree, Mass General Research Scholar.
Department of Biochemistry and Molecular MedicineUniversité de MontréalBiographyDr. Alain Moreau is a Full Professor in the Faculty of Dentistry (Stomatology Department), cross-appointed to the Biochemistry and Molecular Medicine Department in the Faculty of Medicine at Université de Montréal. He served as Director of Research and Chief Scientific Officer of Sainte-Justine University Hospital (2013-2016). More recently, he was appointed Director of The Network for Canadian Oral Health Research for a three-year term commencing effective October 1st, 2016. He currently serves on the advisory board of the Institute of Musculoskeletal Health and Arthritis of the Canadian Institutes of Health Research. He is an internationally recognized expert on molecular genetics of pediatric scoliosis with discoveries that have led to multiple peer-reviewed papers, international conferences as a guest speaker, awards as well as over 50 patents covering innovative diagnostic tests and therapeutic molecules. Dr. Moreau's main research interests also target complex adult diseases such as osteoarthritis, osteoporosis and myalgic encephalomyelitis.
Institute of Stroke and Dementia Research (ISD)Klinikum der Universität MünchenBiographyResearch interests: pathophysiology and therapy of ischemic and hemorrhagic stroke, cardiac arrest-induced brain damage, traumatic brain injury, and age-induced dysfunctions with special emphasis on the neuro-vascular unit.
Coming from the Royal College of Surgeons Ireland (RCSI), Prof. Plesnila and team joined the ISD in October 2011. The Laboratory of Experimental Stroke Research is devoted to uncover the pathophysiology of ischemic and hemorrhagic stroke as the basis for the development of novel therapeutic options for stroke patients. Accordingly, the laboratory of experimental stroke research has become an integral part of ISD’s translational research strategy.
The main expertise of the laboratory gathers around experimental stroke models (transient & permanent focal cerebral ischemia, global ischemia, subarachnoid hemorrhage) and around methodologies for the investigation of the cerebral microcirculation (intravital microscopy using conventional and 2-photon excitation).
The scientific focus of Prof. Plesnila‘s work is the role of neurovascular stress, degeneration (“vasculodegeneration“), and dysfunction for the pathopysiology of acute and chronic stroke syndromes. Specifically, the laboratory will work on the pathophysiology of microcirculatory dysfunction (including the blood-brain barrier) and small vessel disease (SVD).
Chandan K. SenProfessor
Department of SurgeryOhio State UniversityBiographyDr. Chandan K. Sen is a tenured John H & Mildred C Lumley Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Industry Partnership at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his Ph.D. in Physiology from the University of Eastern Finland (Kuopio). Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. A major focus on Dr. Sen's research is to induce tissue plasticity in vivo. He and his collaborators have developed the Tissue Nanotransfection (TNT) technology which was published in Nature Nanotechnology in 2017 and won the 2018 Edison Award for medical innovation. Dr. Sen and his team have published over 300 scientific publications. He has a H-index of 87 and is currently cited over 2100 times every year for a total of over 28000 times.
Charles N. AllenProfessor
Department of Behavioral NeuroscienceOregon Health & Science UniversityBiographyHumans are often required to maintain rigid schedules for work, school, and social activities at times when their endogenous circadian clock is signaling it is time to sleep. Alterations in the timing of the endogenous clock and the onset of sleep or activity produce significant adverse health outcomes. The long-term goal of our research is to describe the neurological mechanisms responsible for the generation and entrainment of circadian rhythms timing and identify possible targets for the therapeutic intervention of circadian-based disorders. To reach this goal we are studying the role of synaptic and extrasynaptic GABA neurotransmission in identified populations of suprachiasmatic nucleus neurons. We are also examining the role of astrocyte-neuronal interactions in responding to glutamatergic neurotransmission and regulating the strength of coupling between individual suprachiasmatic nucleus neuronal oscillators.
Robin L. CooperAssociate Professor
Department of BiologyUniversity of KentuckyBiographyDr. Robin L. Cooper obtained a dual BS degree (Chemistry and Zoology) from Texas Tech Univ. in 1983. He obtained a Ph.D. in 1989 in Physiology from the School of Medicine, Texas Tech Univ. He then went on for postdoctoral training (1989-1992) at the University of Basel, Sch. of Medicine, Basel, Switzerland and a second postdoctoral stent (1992-1996) in the Department of Physiology at the Univ. Toronto, Sch. of Medicine, Toronto, Canada. He then Joined the Dept. of Biology at the University of Kentucky in 1996 and is now professor and director of the undergraduate neuroscience program at the University of Kentucky. He also obtained a BSN in nursing in 2012 and practiced nursing as an RN from 2011 to 2017. He has received several teaching awards: Kentucky Academy of Sciences Excellence in high education teaching, Arts and Sciences Excellence in undergraduate mentoring and, Provost Award for excellence in teaching.
Department of BiologyUniversity of Texas at San Antonio BiographyGeorge Perry is Dean of the College of Sciences, professor of biology, and holds the Semmes Foundation Distinguished University Chair in Neurobiology at The University of Texas at San Antonio. https://www.utsa.edu/sciences/about/dean-bio.html He is recognized in the field of Alzheimer disease research, where he has studied essentially every aspect of the disease, including amyloidosis, oxidative stress, cytoskeleton, metal homeostasis, cell cycle reentry, and mitochondria. For almost 20 years, Perry has been a strong advocate for greater diversity in ideas to move the field forward.
Perry obtained his Bachelor of Arts degree in zoology with high honors from University of California, Santa Barbara. After graduation, he headed to Scripps Institution of Oceanography, Hopkins Marine Station and Woods Hole, and obtained his Ph.D. in marine biology. He then received a postdoctoral fellowship in the Department of Cell Biology at Baylor College of Medicine.
In 1982 Perry joined the faculty of Case Western Reserve University, rising to Professor and Interim Chair of Pathology, and currently holds an adjunct appointment. He is distinguished as the top Alzheimer’s disease researcher by Expertscape with over 1,000 publications, one of the top 100 most-cited scientists in neuroscience and behavior, and one of the top 25 scientists in free radical research. https://en.wikipedia.org/wiki/George_Perry_(neuroscientist).
Perry has been cited over 78,000 (H=141) times and is recognized as a Thompson-Reuters highly cited researcher. He is editor for numerous journals and is editor-in-chief for the Journal of Alzheimer's Disease, the most cited and prolific journal in Alzheimer research. He is a fellow of the American Association for the Advancement of Science, Texas Academy of Science, the Microscopy Society of America, past-president of the American Association of Neuropathologists and the Southwestern and Rocky Mountain Division of the American Association for the Advancement of Science, a member of the Dana Alliance for Brain Initiatives, and a Fulbright Senior Specialist.
Perry is recognized internationally for his research in Alzheimer and promotion of science throughout the Iberian world. He is a Foreign Correspondent Member of the Spanish Royal Academy of Sciences, the Academy of Science Lisbon, and a Foreign Member of the Mexican National Academy of Sciences. He is also a recipient of the National Plaque of Honor from the Republic of Panama Ministry of Science and Technology, and an honorary doctorate from Arturo Prat University, Chile.
Sathyanarayanan V. PuthanveettilAssociate Professor
Department of NeuroscienceThe Scripps Research Institute,FloridaBiographyDr. Sathya Puthanveettil is an Associate Professor in the Department of Neuroscience at the Florida campus of the Scripps Research Institute. Research in his laboratory centers on the molecular and cellular basis of long-term memory storage and its disorders. His laboratory explores these questions using an integrated approach that combines several high throughput techniques with electrophysiology, biochemistry and imaging. He uses Aplysia and mice as models to address these questions at both the cellular and systems level.
Dr. Puthanveettil received his bachelor’s degree in agriculture from Kerala Agricultural University in India and his Ph.D. from Washington State University. He was a postdoctoral fellow in the laboratory of Nobel winner, Dr. Eric Kandel, at Columbia University Medical Center, Howard Hughes Medical Institute prior to joining Scripps.
Botir SagdullaevAssociate Professor
Department of Ophthalmology and NeuroscienceWeill Cornell Medical CollegeBiographyBotir Sagdullaev, Ph.D. is an Associate Professor and Associate Director at the Burke Medical Research Institute at Weill Cornell Medicine in New York, USA. Following his undergraduate studies in physiology at Uzbek National University and graduate studies in biophysics, Dr. Sagdullaev performed his post-doctoral research work at University of Louisville and Washington University School of Medicine in St. Louis. In 2005, he was awarded the James O’Leary Prize for excellence in neuroscience. Botir has joined the faculty at Columbia University (2006) and Weill Cornell Medicine (2008), where he continues to focus his research on sensory signal processing, particularly on how fundamental yet simple synaptic mechanisms underlie our perception of the world around us. His laboratory studies how the sensory system is shaped by elaborate neurovascular circuitry and how it is altered by development, experience or during neurodegenerative diseases.
Kai-Christian SonntagAssociate Professor
Department of PsychiatryHarvard Medical SchoolBiographyDr. Sonntag received his MD degree in 1993 and his PhD degree in Virology in 1994 from University of Heidelberg, Germany. After an internship in Internal Medicine from 1993-1994, he worked as a Research Scientist in the Department of Virology at University of Heidelberg until 1995 when he became a Research Fellow in the Transplantation Biology Research Center at Massachusetts General Hospital, Boston. In 2000, he took a position as an Assistant Research Stem Cell Biologist in the Center for Neuroregeneration at McLean Hospital, Belmont, MA, and became an Instructor in Psychiatry at Harvard Medical School. In 2004 he was promoted to Associate Stem Cell Biologist and in 2005 to Assistant Professor in Psychiatry (Neuroscience).
Dr. Sonntag is a molecular and cellular biologist and has extensive expertise in the fields of virology, immunology, and neurobiology. In his early career, Dr. Sonntag’s work has contributed to understanding the molecular evolution and biology of large DNA viruses, and to develop a gene therapy approach based on lentivirus vector technology and genetically modifying bone marrow stem cells to induce transplantation tolerance to organ grafts. His current scientific interest is to understand the molecular and cellular mechanisms and factors governing neuronal function and dysfunction in the aging brain and in neurodegenerative or neurological diseases. Dr. Sonntag’s research has contributed to developing novel technologies and systems, including pluripotent stem cell paradigms for neurogenesis, and lentivirus-mediated gene-engineering, as tools to study molecular mechanisms in neurodegeneration and neurological disorders, and as a source for cell therapy, such as the production of dopaminergic cell grafts to treating Parkinson's disease (PD). Among others, his work has also contributed to understanding a role of dopamine D1 and adrenergic receptors in hedonic and impulsive behavior, dysregulated gene and miRNA expression networks in PD and schizophrenia, a novel mechanism to regulate neurotrophic growth factor-associated signaling pathways by miRNAs in context of PD and Alzheimer’s disease (AD)-associated toxic insult, and more recently, dysfunctional bioenergetics in the pathogenesis of late-onset AD (LOAD). Dr. Sonntag serves on several editorial boards and committees.
Ryan ThummelAssistant Professor
Department of Anatomy and Cell BiologyWayne State UniversityBiographyI received my Ph.D. in Developmental Genetics in 2004 under the training of Alan Godwin, Ph.D. at the University of Kansas Medical Center. As a post-doc in David Hyde’s lab at the University of Notre Dame, I developed an in vivo electroporation technique to use morpholinos for targeted knockdown of genes of interest during retinal regeneration in adult zebrafish. This technique was used to definitively showed that Müller glia are the source of retinal progenitors during retinal regeneration in the adult zebrafish. I joined the faculty of Wayne State University School of Medicine in 2009. My lab continues to use zebrafish as a model to study retinal and CNS development, retinal regeneration in adults, and cancer biology. We have trainees at every level in the lab and have two zebrafish facilities to support our research programs. I am also part of team of faculty responsible for teaching the first year curriculum to our medical students. Please visit our lab website to learn more about our work. https://thummellab.weebly.com/
Veterinary Advisory Board and Veterinary Reviewers
Our Veterinary Advisory Board members are selected from key opinion leaders within the research veterinary community and have a special interest in animal welfare, safety, handling and care. The Veterinary Reviewers review all JoVE articles requiring live animal work to ensure that proper welfare and sterility standards are observed.
Veterinary Advisory Board
- Scott Perkins (Head)Senior Director
Division of Laboratory Animal Medicine
Associate ProfessorTufts University
- Marilyn BrownExecutive Director
Animal Welfare and TrainingCharles River Laboratories
- Lynn JacksonComparative Medicine Consultant
- Barbara SmithSenior Director
Animal Resources FacilityDana-Farber Cancer Institute
- Trinka Adamson Beckman Research Institute
- Megan AlbertelliAssistant Professor
Department of Comparative MedicineStanford University
- Bernadette AlisantosaAttending VeterinarianAvanza Laboratories
- Ken Allen Medical College of Wisconsin
- Amy Andrews Mayo Clinic
- Damodaran Annamalai Massachusetts Institute of Technology
- Jill Ascher FDA Center for Biologics Evaluation & Research
- Jennifer Asher Yale University
- Ari Aycock-Williams University of Southern California
- Janet Baer Cal Tech
- Ron BanksDirector
Division of Comparative MedicineUniversity of Oklahoma Health Sciences Center
- Corinna Beale Tufts University
- Catherine Beckwith Independent consultant
- Terry Besch US Army
- Leslie Birke LSU Health Science Center
- Terry BlankenshipChief
Veterinary Medicine SectionNIEHS, NIH
- Chris Boehm Texas Tech University Health Sciences Center
- David BrammerExecutive Director
Animal Care OperationsUniversity of Houston
- Matt Breed Frederick National Laboratory for Cancer Research
- Kelvin Buchanan US Army
- Larry CarboneSenior Veterinarian and Associate Director
Lab Animal Resource CenterUniversity of California San Francisco
- David Chu Stanford University
- Helen Chum VA Palo Alto Health Care System
- Judy Coman Abbvie Inc.
- Laura ConourDirector
Research ResourcesPrinceton University
- Tara Cotroneo Wayne State University
- Suzanne CraigAssociate ProfessorMedical University of South Carolina
- Stephen Dalal MRMC, Fort Detrick, MD
- Marie Debrue Pfizer
- Louis DeTollaChief
Veterinary ResourcesUniversity of Maryland
- Sandra Duarte Vogel UCLA
- Pradeep Dumpala Rogosin Institute
- Melissa DysonAssistant Professor
Unit for Laboratory Animal MedicineUniversity of Michigan
- Christine Ege Defense Intelligence Agency
- Dil Ekanayake-Alper Columbia Center for Transplant Immunology
- Robyn Engel National Institute of Health
- Brian Ermeling Scripps (Florida)
- Michael Esmail Tufts University
- Laura Eurell University of Florida
- Judy Fenyk-MelodyDirectorPfizer
- James Finlay University of Southern California
- Dawn FitzhughChief
Veterinary Medicine and Surgery BranchOffice of The Surgeon General
- Charmaine FoltzDirector
Division of Veterinary ResourcesDivision of Veterinary Resources, NIH
- Diane Gaertner University of Pennsylvania
- Montip GettayacaminRegional DirectorAAALAC International, Southeast Asia Office
- Sylvia GografeDirector
Comparative MedicineFlorida Atlantic University
- Jim GoodrichAssistant Professor of Comparative MedicineYale University
- Lauren Habenicht Harvard University
- Joseph Hampel MPI Research
- Claudia Harper Biogen Idec
- Dana Hasselschwert New Iberia Research Center
- James HawkinsAnimal Program DirectorNHLBI, NIH
- Kristi Helke Medical University of South Carolina
- Lara Helwig Brown University
- Annette Hildabrand Independent consultant
- Lori Hill MD Anderson Cancer Center
- Christian C. Hofer Walter Reed Army Institute of Research
- Matthew Hogan Massachusetts General Hospital
- Todd Jackson Oklahoma State University
- Erin Jackson University of Pittsburgh
- Donna Matthews Jarrell Massachusetts General Hospital
- Vanessa Jensen MD Anderson Cancer Center
- Stephanie Jensen Independent consultant
- Kelly Jensen Independent consultant
- David Johnson Cascades Biosciences Consultants, Inc.
- Nancy Johnston Indiana University School of Medicine
- Mahesh Jonnalagadda University of Cincinnati
- Brian Karolewski Franklinville Veterinary Services
- Robin Kastenmayer AstraZeneca (Sweden)
- Mary Kennett Pennsylvania State University
- Mark Klinger Nathan Kline Institute
- Craig Koeller Air Force Research Laboratory
- Krishnan Kolappaswamy Harlan Laboratories, Inc.
- Josh Kramer National Cancer Institute
- George LanganDirector
Animal Resources CenterUniversity of Chicago
- Mathias Leblanc The Salk Institute for Biological Studies
- David Lee-Parritz Tufts University (veterinary school)
- Patrick Lester University of Michigan
- Jori LeszczynskiUniversity Veterinarian and Director
Office of Laboratory Animal ResourcesUniversity of Colorado, Denver
- James LevinDirectorPerkins & Will
- Claire Lindsell University of California Irvine
- Jennifer Lofgren University of Michigan
- Sean Maguire GlaxoSmithKline
- M.A. McCrackin Medical University of South Carolina
- Andres Mejia Wisconsin National Primate Research Center
- Nancy Merrill US Army
- David Moore Virginia Tech
- Erin N.Z. Yu Vanderbilt University Medical Center
- Kate NaffAssociate Professor
Veterinary Medicine & SurgeryMD Anderson Cancer Center
- Claude NagamineDirector
Rodent Services and Rodent Health SurveillanceStanford University
- Joe NewsomeClinical Director
Division of Laboratory Animal ResourcesUniversity of Pittsburgh
- Megan Nowland University of Michigan
- Jane OlinSenior DirectorEdwards LifeSciences
- Sharon Ostergaard Bristol-Myers Squibb
- Glen Otto University of Texas at Austin
- James OwinyUniversity VeterinarianColorado State University
- Jassia Pang National University of Singapore
- Calvin Patten University of Texas Medical Branch
- Cynthia PekowChief
Veterinary Medical UnitSeattle VA Medical Center
- Jocelyn Penner Pacific Northwest National Laboratory
- Norman PetersonLaboratory Animal VeterinarianMedImmune
- Lisa Portnoy NIH Clinical Center
- Richard Rahija St. Jude Children's Research Hospital
- Cliff Roberts SFVAMC
- Gordon Roble New York University School of Medicine
- Janet RodgersVeterinary SurgeonIndependent consultant
- Nancy Rodriguez Independent consultant
- Allison Rogala University of North Carolina at Chapel Hill
- Shawn Rosensteel Virginia Commonwealth University
- Sara Savage Sanofi
- Jacqueline Scapa Harvard University
- David SchabdachUniversity Veterinarian and Director
University Laboratory Animal ResourcesUniversity of Pittsburgh
- Jodi Carlson ScholzAssistant Professor
Section of Comparative MedicineMayo Clinic
- Diana Scorpio National University of Singapore
- Manu SebastianAssociate Professor
Department of Epigenetics and Molecular CarcinogenesisExperimur
- Tim Settle Uniformed Services University of the Health Sciences
- Kathryn Shelton MD Anderson Cancer Center
- Nirah ShomerDirector of Laboratory Animal ResourcesIndependent consultant
- Jerald Silverman UMass Medical
- Mikele Simkins Pfizer
- Laura Singer Independent consultant
- Brianna Skinner Centers for Disease Control
- Joanne Smith NIH
- Catherine Sohn Genentech
- Raja Sriperumbudur Biogen Idec
- Marisa St. ClaireChief Veterinary Medical Officer
Office of the Chief Scientist, IRFNIH/NIAID
- Karen StraitAssociate Veterinarian
Yerkes National Primate Research CenterT3 Labs, Emory Healthcare
- Rachel Strittmatter Cold Spring Harbor Laboratory
- Maggie Struck University of Florida
- Mark SuckowDirector
Freimann Life Science CenterUniversity of Minnesota
- Christopher SuckowVeterinary Medical OfficerUniversity of Texas Medical Branch
- Alton Swennes Baylor College of Medicine
- Keely Szilágyi Indiana University School of Medicine
- Mike TalcottDirector
Veterinary Surgical ServicesWashington University St. Louis
- Laura Tambrallo Merial
- Betty Theriault Univeristy of Chicago
- Anita Trichel University of Pittsburgh
- Sai Tummala Oklahoma Medical Research Foundation
- Patricia TurnerProfessor and Program Leader
Laboratory Animal ScienceOntario Veterinary College
- Rajesh K. Uthamanthil Fred Hutchinson Cancer Research Center
- Tracy VemulapalliClinical Associate Professor of Laboratory Animal Medicine Director, Comparative Medicine Residency Training Program College of Veterinary Medicine & Biomedical Sciences
Texas A&M University
- Meghan Vermillion Johns Hopkins University
- Cristina Weiner Taconic
- Tiffany Whitcomb Penn State Hershey College of Medicine
- Jennifer Wilk Legacy Research Institute
- Misty Williams CBSET
- Angelina Williams University of Houston
- Ron WilsonProfessor and Chair
Department of Comparative MedicinePenn State Hershey College of Medicine
- Steve WilsonAssistant Professor
Section of Comparative MedicineYale University
- Jolaine Wilson Janssen Research & Development, LLC
- Susan Wilson-Sanders University of Arizona
- Marissa Wolfe Medical University of South Carolina
- Nicolette Zielinski Mozny Northwestern University