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Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat

Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat

Article DOI: 10.3791/2432 11:12 min
February 7th, 2011


Summary February 7th, 2011

The hyperinsulinemic-euglycemic clamp is the "gold standard" for the assessment of insulin action. Insulin is infused at a constant rate stimulating glucose uptake. The amount of exogenous glucose infused to counter this drop is indicative of insulin sensitivity. Here the procedure is performed on a conscious, unrestrained rat.

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