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Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
JoVE Journal
Medicine
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JoVE Journal Medicine
Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
DOI:

09:25 min

June 28, 2013

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Chapters

  • 00:05Title
  • 01:46Pancreatic Cancer Cell Preparation
  • 02:59Mouse Preparation
  • 03:45Laparotomy
  • 06:18Bioluminescent Tracking of Pancreatic Cancer Progression
  • 07:33Results: Bioluminescent Imaging, Growth Kinetics, and Histological Analysis of Orthotopic Pancreatic Tumors
  • 08:58Conclusion

Summary

Automatic Translation

Improved understanding of pancreatic cancer biology is critically needed to enable the development of better therapeutic options to treat pancreatic cancer. To address this need, we demonstrate an orthotopic model of pancreatic cancer that permits non-invasive monitoring of cancer progression using in vivo bioluminescence imaging.

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