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阻隔组织破坏与有机电化学晶体管传感

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

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阻隔组织破坏与有机电化学晶体管传感

DOI:

10.3791/51102-v

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11:17 min

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February 10, 2014

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Scherrine A. Tria, Marc Ramuz, Leslie H. Jimison, Adel Hama, Roisin M. Owens

¹Department of Bioelectronics,Ecole Nationale Superieure des Mines, ²Research and Exploratory Development Division, Applied Physics Laboratory,Johns Hopkins University

Chapters

00:05Title
02:05Organic Electrochemical Transistor Fabrication
04:46Device Assembly
05:35Cell Culture
06:20Measurements with OECT and Cell Integration
07:50Preparatin and Introduction of Toxic Compound
08:39Results: Sensing of Barrier Tissue Disruption with and OECT
10:31Conclusion

Summary

Automatic Translation

有机电化学晶体管集成了活细胞，并用于监视整个胃肠道上皮屏障离子流。在本研究中，增加了离子通量，涉及到中断紧密连接的，诱导的钙螯合剂EGTA（乙二醇 - 双（β-氨基乙基醚）-N，N，N'，N'-四乙酸的存在下酸），进行测定。

Tags

Organic Electrochemical Transistor Gastrointestinal Tract EGTA Paracellular Flux Transepithelial Resistance Drug Discovery Pathogen/toxin Diagnostics High-throughput Screening

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