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Journal / Immunology and Infection / Overvågning Aktivering af Antiviral…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Overvågning Aktivering af Antiviral Mønstergenkendelse Receptorer RIG-I og PKR Af Limited proteasefordøjelse og Native SIDE
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Three-dimensional Imaging of Bacterial Cells for Accurate Cellular Representations and Precise Protein Localization
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Overvågning Aktivering af Antiviral Mønstergenkendelse Receptorer RIG-I og PKR Af Limited proteasefordøjelse og Native SIDE

Article DOI: 10.3791/51415-v • 12:43 min • July 29th, 2014
July 29th, 2014 •
1, 1
1Institute for Virology, Philipps-University Marburg

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Medfødte forsvar mod virusinfektioner er udløst af mønstergenkendelse receptorer (PRRS). De to cytoplasmatiske PRRs RIG-I og PKR binder til virale signatur RNA'er, ændre kropsbygning, oligomerisere og aktivere antiviral signalering. Metoder er beskrevet som tillader bekvemt overvåge konformationelle kobling og oligomerisering af disse cytoplasmatiske PRRs.

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Infektionssygdomme medfødte immunrespons virusinfektion patogen genkendelse receptor RIG-I PKR IRF-3 begrænset proteasespaltning konformational switch indfødte PAGE oligomerisering
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