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중간 과산화물을 통해 광화학 및 산 - 촉매 CH 기능화에 의한 항 바이러스 Tetrahydrocarbazole 유도체의 합성 (CHIPS)
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
DOI:

06:34 min

June 20, 2014

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Chapters

  • 00:05Title
  • 01:34Synthesis of Tetrahydrocarbazole Hydroperoxides
  • 02:45Coupling Reaction – Method A Using 10 mol% Trifluoroacetic Acid in Methanol
  • 04:03Coupling Reaction – Method B Using Acetic Acid
  • 04:52Results: Synthesis of Pharmaceutically Active Tetrahydrocarbazoles
  • 06:06Conclusion

Summary

Automatic Translation

A two-step procedure for the synthesis of pharmaceutically active indole-derivatives by C-H functionalization with anilines is described, using photo- and Brønsted acid catalysis.

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