We describe a surgical technique that produces wire injury in the femoral artery of mice to induce neointimal hyperplasia to serve as a model testing system for the perivascular delivery of therapeutic compounds for the inhibition of restenosis.
Le, V., Johnson, C. G., Lee, J. D., Baker, A. B. Murine Model of Femoral Artery Wire Injury with Implantation of a Perivascular Drug Delivery Patch. J. Vis. Exp. (96), e52403, doi:10.3791/52403 (2015).