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Induction of Accelerated Atherosclerosis in Mice: The “Wire-Injury” Model
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Medicine
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JoVE Journal Medicine
Induction of Accelerated Atherosclerosis in Mice: The “Wire-Injury” Model

Induction of Accelerated Atherosclerosis in Mice: The “Wire-Injury” Model

DOI:
10.3791/54571-v

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00:05 min

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August 25, 2020

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, , ,
1Institute for Molecular Cardiovascular Research,RWTH Aachen University, 2Human Genetic Laboratory,University of Medicine and Pharmacy

Chapters

  • 00:04Title
  • 00:38Hyperlipidemia Inducement and Wire Injury
  • 03:53Results: Representative Restenosis Plaque Analysis
  • 05:02Conclusion

Summary

Automatic Translation

Automatic Translation

This study describes an invasive procedure for the induction of accelerated atherosclerosis in mice. In comparison to other methods using electric- or cryo-induced injury, mechanical-induced injury mimics the human condition of restenosis after revascularization therapies and is ideal for the study of the molecular mechanisms involved.

Tags

Keywords: Wire-injury ModelAccelerated AtherosclerosisMouse ModelCarotid ArteryEndothelial DenudationHyperlipidemiaAtherogenic DietRevascularizationRestenosisMolecular MechanismsInjury Response

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