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JoVE Journal
Medicine

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Induction of Accelerated Atherosclerosis in Mice
 

Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model

Article DOI: 10.3791/54571-v
August 25th, 2020

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Summary August 25th, 2020

This study describes an invasive procedure for the induction of accelerated atherosclerosis in mice. In comparison to other methods using electric- or cryo-induced injury, mechanical-induced injury mimics the human condition of restenosis after revascularization therapies and is ideal for the study of the molecular mechanisms involved.

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