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Paw-Dragging: a Novel, Sensitive Analysis of the Mouse Cylinder Test
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JoVE Journal Behavior
Paw-Dragging: a Novel, Sensitive Analysis of the Mouse Cylinder Test

Paw-Dragging: a Novel, Sensitive Analysis of the Mouse Cylinder Test

DOI:
10.3791/52701-v

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09:14 min

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April 29, 2015

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,
1BioMedical Sciences, Faculty of Medicine,Memorial University of Newfoundland, 2Neurosciences, Faculty of Medicine,McGill University

Chapters

  • 00:00Title
  • 00:14Introduction
  • 03:07Set-up of the Mouse Cylinder Test
  • 04:32Conducting the Mouse Cylinder Test
  • 05:07Analysis of the Mouse Cylinder Test
  • 05:54Quantifying Paw Dragging Behavior
  • 06:59Identifying Behavior that is not a Paw Drag
  • 07:53Representative Results
  • 08:31Conclusion

Summary

Automatic Translation

Automatic Translation

Classical forelimb asymmetry analysis of the cylinder test is routinely used to assess behavioural deficits in rats following brain injury or stroke; however, it fails to detect consistent deficits in mice. This study demonstrates that quantifying paw-dragging behaviour is a more sensitive analysis of brain injury in mice.

Tags

Keywords: Paw-draggingMouse Cylinder TestFocal Ischemic DamageForelimb AsymmetryForelimb Motor CortexCortical Ischemic InjuryPhotothrombosisEndothelin-1Functional RecoveryTransgenic Mouse Strains

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