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JoVE Journal
Developmental Biology

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Adenoviral Gene Therapy for Diabetic Keratopathy

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Article DOI: 10.3791/54058
April 7th, 2016


Summary April 7th, 2016

An example of adenoviral gene therapy in the human diabetic organ-cultured corneas is presented towards the normalization of delayed wound healing and markedly reduced epithelial stem cell marker expression in these corneas. It also describes the optimization of this process in stem cell-enriched limbal epithelial cultures.


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