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التنكس العصبي في نموذج حيواني من المزمن اميلويد بيتا قليل وحدات ضخ وتصدى بواسطة الأجسام المضادة العلاج يملؤه المضخات الأسموزية
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
DOI:

10:19 min

August 14, 2016

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Chapters

  • 00:05Title
  • 00:51Implantation of Cannula
  • 04:32Osmotic Pump Installation
  • 05:47Aβo Infusion in Awake and Freely Moving Rats
  • 08:43Results: Neuronal Loss Induced by Aβo Deposition is Attenuated by 6E10 Antibody Treatment
  • 09:23Conclusion

Summary

Automatic Translation

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

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