In Vitro permeação de Ferritinas FITC-carregados através de um Rat barreira sangue-cérebro: um modelo para estudar a Entrega de Nanoformulated Moléculas
A method to establish an in vitro model of blood-brain barrier based on a co-culture of rat brain microvascular endothelial cells and astrocytes is described and validated. This system proved to be a valid tool to study the effect of nanoformulation on the trans-barrier permeation of fluorescent molecules.