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1Department of Surgery,University of Maryland School of Medicine, 2Department of Medicine,University of Maryland School of Medicine, 3Department of Radiology,University of Maryland School of Medicine, 4Food and Drug Administration, 5Department of Pharmaceutical Sciences,University of Maryland School of Pharmacy, 6VA Maryland Health Care System
Chapters
- 00:05Title
- 00:5919F-Labeled Bile Acid Gavage, Organ Harvest and Bile Acid Measurement
- 04:02Live Animal Proton (1H) and Fluorine (19F) Magnetic Resonance Imaging (MRI)
- 05:51Results: Representative Multi-fluorinated Bile Acid (MFBA) Measurement in the Mouse Gallbladder
- 07:51Conclusion
Værktøjer til at diagnosticere galdesyre malabsorption og måle galdesyretransport in vivo er begrænsede. En innovativ tilgang med levende dyr beskrives der bruger kombineret proton (1H) plus fluor (19F) magnetisk resonans; denne hidtil ukendte metodik har translationel potentiale til at screene for galdesyre malabsorption i klinisk praksis.
