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Journal / Genetics / Ingeniør Kunstige Faktorer å Spesifikt Manipulere …
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JoVE Journal Genetics
Ingeniør Kunstige Faktorer å Spesifikt Manipulere alternativ spleising i humane celler
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Ingeniør Kunstige Faktorer å Spesifikt Manipulere alternativ spleising i humane celler

Article DOI: 10.3791/54967-v • 10:06 min • April 26th, 2017
April 26th, 2017 •
*1, *1, 2, 1, 1, 1, 1
1Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences (SIBS), 2Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University
* These authors contributed equally

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Denne rapporten beskriver en bioengineeringsmetode for å designe og konstruere nye kunstige spleisningsfaktorer (ASFs) som spesifikt modulerer spleising av målgener i pattedyrceller. Denne metoden kan utvides ytterligere til å konstruere ulike kunstige faktorer for å manipulere andre aspekter av RNA-metabolisme.

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Genetikk utgave 122 kunstige RNA bindingsfaktorer protein engineering spleisningsfaktorer alternativ spleising PUF stillas RNA bindende proteiner kreft
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