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Um Mouse 5/6th nefrectomia modelo que induz a miocardiopatia urêmica Experimental
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Um Mouse 5/6th nefrectomia modelo que induz a miocardiopatia urêmica Experimental

Article DOI: 10.3791/55825 • 07:52 min
November 7th, 2017 •
*1, *2, 2, 1, 2, 1,2
1Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, 2Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine
* These authors contributed equally

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November 7th, 2017

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Este manuscrito fornece um procedimento cirúrgico de duas etapas detalhadas para executar o rato 5/6th nefrectomia parcial (PNx) com ligadura de polo. Quatro semanas após a cirurgia, em comparação com a operação de ratos, os ratos PNx desenvolveram insuficiência renal, anemia, hipertrofia cardíaca, Fibrose cardíaca e diminuição da função sistólica e diastólica do coração.

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