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一种诱导实验性尿毒症心肌病的小鼠 5/6th肾切除模型
JoVE Journal
Biology
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JoVE Journal Biology
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
DOI:

07:52 min

November 07, 2017

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Chapters

  • 00:05Title
  • 01:00Left Kidney Pole Ligation
  • 03:50Right Kidney Removal
  • 05:09Results: Representative Effects of Left Kidney Polar Ligation
  • 06:39Conclusion

Summary

Automatic Translation

这份手稿提供了一个详细的 two-step 手术程序执行小鼠 5/6th部分肾切除 (PNx) 与极结扎。手术后四周, 与假手术小鼠相比, PNx 小鼠肾功能受损, 贫血, 心肌肥厚, 心脏纤维化, 心脏收缩和舒张功能下降。

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