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Journal / Chemistry / Genetiske kodingen for en ikke-kanoniske…
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Chemistry

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JoVE Journal Chemistry
Genetiske kodingen for en ikke-kanoniske aminosyre for generering av antistoff-stoff Conjugates gjennom en rask Bioorthogonal reaksjon
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Genetiske kodingen for en ikke-kanoniske aminosyre for generering av antistoff-stoff Conjugates gjennom en rask Bioorthogonal reaksjon

Article DOI: 10.3791/58066-v • 11:02 min • September 14th, 2018
September 14th, 2018 •
1
1Medical Research Council Laboratory of Molecular Biology

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Innlemme en cyclopropene derivat av lysin i antistoffer kan områdespesifikke, rask og effektiv sammenhengen av tetrazine-bærende molekyler å generere antistoff-stoff conjugates.

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Kjemi problemet 139 antistoff-stoff conjugates bioorthogonal reaksjoner cyclopropene narkotika-leveranser protein engineering bioconjugation
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