Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Csilla Ari; Dominic P. D&#8217;Agostino; David M. Diamond; Mark Kindy; Collin Park; Zsolt Kov&#225;cs

doi:10.3791/58396

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Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

JoVE Journal
Behavior

This content is Free Access.

JoVE Journal Behavior

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

30,743 Views

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05:42 min

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January 07, 2019

DOI:

10.3791/58396-v

DOI:

10.3791/58396-v

•

05:42 min

January 07, 2019

•

32 Views

Csilla Ari¹, Dominic P. D’Agostino^2,3, David M. Diamond^1,2, Mark Kindy^4,5,6, Collin Park¹, Zsolt Kovács⁷

¹Department of Psychology, Hyperbaric Neuroscience Research Laboratory,University of South Florida, ²Department of Molecular Pharmacology and Physiology, Metabolic Medicine Research Laboratory, Morsani College of Medicine,University of South Florida, ³Institute for Human and Machine Cognition, ⁴Department of Pharmaceutical Sciences, College of Pharmacy,University of South Florida, ⁵James A. Haley VA Medical Center, ⁶Shriners Hospital for Children, ⁷Savaria Department of Biology,ELTE Eötvös Loránd University

Summary

Here, we present a protocol to investigate changes in the anxiety level of rodent animal models. The elevated plus maze (EPM) test, used together with a video tracking software, provides a reliable method to document the effect of various potential anxiolytic treatments in preclinical laboratory scenarios.