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JoVE Journal Neuroscience
Convectie verbeterde levering van Optogenetische adeno-geassocieerde virale vector aan de cortex van rhesus macaque onder begeleiding van online MRI-beelden
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Convectie verbeterde levering van Optogenetische adeno-geassocieerde virale vector aan de cortex van rhesus macaque onder begeleiding van online MRI-beelden

Article DOI: 10.3791/59232-v • 08:52 min • May 23rd, 2019
May 23rd, 2019 •
1,2, 2,3, 4, 1,2,3,4
1Departments of Bioengineering, University of Washington, 2Washington National Primate Research Center, 3Department of Electrical and Computer Engineering, University of Washington, 4Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco

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Hier demonstreren we magnetische resonantie (MR)-geleide convectie verbeterde levering (CED) van virale vectoren in de cortex als een efficiënte en vereenvoudigde aanpak voor het bereiken van optogenetische expressie in grote corticale gebieden in de makaak hersenen.

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Neurowetenschappen uitgave 147 Optogenetica niet-menselijke primaten rhesus-macaques virale vector levering Opsin-expressie primaire motorische cortex primaire Somatosensorische cortex
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