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Journal / Medicine / Generering av ventrikkel-lignende HiPSC-avledet…
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JoVE Journal Medicine
Generering av ventrikkel-lignende HiPSC-avledet Cardiomyocytes og høy kvalitet Cell forberedelser for kalsium håndtering karakterisering
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Generering av ventrikkel-lignende HiPSC-avledet Cardiomyocytes og høy kvalitet Cell forberedelser for kalsium håndtering karakterisering

Article DOI: 10.3791/60135-v • 08:06 min • January 17th, 2020
January 17th, 2020 •
1, 1, 1, 1
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai

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Her beskriver vi og validerer en metode for å konsekvent generere robuste menneskelige indusert pluripotent stilk celle-avledet cardiomyocytes og karakterisere deres funksjon. Disse teknikkene kan hjelpe i å utvikle mekanistisk innsikt i signalering trasé, gir en plattform for stor skala narkotika screening, og pålitelig modell hjertesykdommer.

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Medisin indusert pluripotent stilk cellen-avledet cardiomyocytes (iPSC-CMs) iPSCs kalsium transient kalsium håndtering CARDIAC sykdom modellering cardiomyocyte modning
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