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A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
JoVE Journal
Medicine
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JoVE Journal Medicine
A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
DOI:

09:03 min

November 15, 2019

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Chapters

  • 00:04Title
  • 01:24Ocular Hypertension Induction by Intracameral Injection of Silicone Oil
  • 02:33Intracameral Silicon Oil Injection for One Eye
  • 04:30Silicone Oil Removal
  • 05:59IOP (Intraocular Pressure) Measurement Once a Week
  • 07:02Results: Quantification of Silicon Oil-Induced Ocular Hypertension and Degeneration in Mice
  • 08:19Conclusion

Summary

Automatic Translation

Here, we present a protocol to induce ocular hypertension and glaucomatous neurodegeneration in mouse eyes by intracameral injection of silicone oil and the procedure for silicone oil removal from the anterior chamber to return elevated intraocular pressure to normal.

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