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Journal / Cancer Research / Ultralyd-guidet Ortotopisk implantation af murin…
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Cancer Research

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JoVE Journal Cancer Research
Ultralyd-guidet Ortotopisk implantation af murin Pankreatisk ductal adenocarcinoma
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Ultralyd-guidet Ortotopisk implantation af murin Pankreatisk ductal adenocarcinoma

Article DOI: 10.3791/60497-v • 06:21 min • November 19th, 2019
November 19th, 2019 •
1, 2,3, 2,3, 2,3, 1,4
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 2Pancreatic Cancer Mouse Hospital, Perelman School of Medicine, University of Pennsylvania, 3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 4Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania

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Vi beskriver en protokol til ultralyd guidet implantation af murine-afledte pancreas duktalt adenocarcinom cellelinjer direkte ind i den indfødte tumor site. Denne fremgangsmåde resulterede i bugspytkirtel tumorer detekterbare ved ultralydsscanning inden for 2-4 ugers injektion, og signifikant reduceret andelen tumor celle såning på peritonealdialyse væggen i forhold til kirurgisk ortotopisk implantation.

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Kræftforskning pancreas duktalt adenokarcinom ultralyd orthotopic prækliniske model
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