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Journal / Cancer Research / Ultraschallgeführte orthotopische Implantation…
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Cancer Research

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JoVE Journal Cancer Research
Ultraschallgeführte orthotopische Implantation von murine Pankreas-Ductalsocarcinom
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Ultraschallgeführte orthotopische Implantation von murine Pankreas-Ductalsocarcinom

Article DOI: 10.3791/60497-v • 06:21 min • November 19th, 2019
November 19th, 2019 •
1, 2,3, 2,3, 2,3, 1,4
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 2Pancreatic Cancer Mouse Hospital, Perelman School of Medicine, University of Pennsylvania, 3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 4Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania

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Wir beschreiben ein Protokoll für die ultraschallgeführte Implantation von murinabgeleiteten duktodrischen Adenokarzinom-Zelllinien direkt in die native Tumorstelle. Dieser Ansatz führte zu Pankreastumoren, die durch Ultraschall-Scanning innerhalb von 2-4 Wochen nach der Injektion nachweisbar waren, und reduzierte den Anteil der Tumorzellsaatierung an der Peritonealwand im Vergleich zur chirurgischen orthotopischen Implantation signifikant.

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Krebsforschung Ausgabe 153 pankreasduktales Adenokarzinom Ultraschall orthotopisches präklinisches Modell
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