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手术小鼠模型中骨关节炎的标准化形态学评价
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Medicine
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JoVE Journal
Medicine
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Please note that all translations are automatically generated.
Click here for the English version.
手术小鼠模型中骨关节炎的标准化形态学评价
DOI:
10.3791/60991-v
•
07:32 min
•
May 06, 2020
•
William J. Pinamont
,
Natalie K. Yoshioka
,
Gregory M. Young
,
Vengadeshprabhu Karuppagounder
,
Elijah L. Carlson
,
Adeel Ahmad
,
Reyad Elbarbary
2
,
Fadia Kamal
3
1
Center for Orthopedic Research and Translational Sciences, Department of Orthopedics and Rehabilitation
,
Pennsylvania State College of Medicine
,
2
Department of Biochemistry and Molecular Biology
,
Pennsylvania State College of Medicine
,
3
Department of Pharmacology
,
Pennsylvania State College of Medicine
Chapters
00:04
Introduction
01:13
Histomorphometric Analysis Setup
01:59
Total, Calcified, and Uncalcified Cartilage Area Measurements
02:47
Chondrocyte Number and Phenotype Evaluation
03:17
Tibial Articular Surface Perimeter Measurement
03:47
Subchondral Bone and Marrow Space Area Measurement
04:30
Anterior and Posterior Osteophyte Area and Synovial Thickness Measurement
05:21
Results: Representative Histomorphometric Osteoarthritis (OA) Evaluation in Destabilization of the Medial Meniscus (DMM) and Sham Mice
07:06
Conclusion
Summary
Automatic Translation
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Automatic Translation
目前的议定书建立了一个严格和可重复的方法,定量与骨关节炎的形态关节变化。该协议的应用对于监测骨关节炎的疾病进展和评估治疗干预具有价值。
Tags
Histomorphometric
Osteoarthritis
Joint Changes
Quantitative Analysis
Cartilage
Bone
Reproducible
Standardized Protocol
Mouse Model
Calcified Cartilage
Chondrocyte
Subchondral Bone
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