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Medicine
/
外科用マウスモデルにおける変形性関節症の標準化組織形態評価
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Medicine
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JoVE Journal
Medicine
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Please note that all translations are automatically generated.
Click here for the English version.
外科用マウスモデルにおける変形性関節症の標準化組織形態評価
DOI:
10.3791/60991-v
•
07:32 min
•
May 06, 2020
•
William J. Pinamont
,
Natalie K. Yoshioka
,
Gregory M. Young
,
Vengadeshprabhu Karuppagounder
,
Elijah L. Carlson
,
Adeel Ahmad
,
Reyad Elbarbary
2
,
Fadia Kamal
3
1
Center for Orthopedic Research and Translational Sciences, Department of Orthopedics and Rehabilitation
,
Pennsylvania State College of Medicine
,
2
Department of Biochemistry and Molecular Biology
,
Pennsylvania State College of Medicine
,
3
Department of Pharmacology
,
Pennsylvania State College of Medicine
Chapters
00:04
Introduction
01:13
Histomorphometric Analysis Setup
01:59
Total, Calcified, and Uncalcified Cartilage Area Measurements
02:47
Chondrocyte Number and Phenotype Evaluation
03:17
Tibial Articular Surface Perimeter Measurement
03:47
Subchondral Bone and Marrow Space Area Measurement
04:30
Anterior and Posterior Osteophyte Area and Synovial Thickness Measurement
05:21
Results: Representative Histomorphometric Osteoarthritis (OA) Evaluation in Destabilization of the Medial Meniscus (DMM) and Sham Mice
07:06
Conclusion
Summary
Automatic Translation
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Automatic Translation
現在のプロトコルは変形性関節症に伴う形態学的関節変化の定量化のための厳密で再現可能な方法を確立する。このプロトコルの適用は、疾患の進行を監視し、変形性関節症における治療介入を評価する上で価値がある。
Tags
Histomorphometric
Osteoarthritis
Joint Changes
Quantitative Analysis
Cartilage
Bone
Reproducible
Standardized Protocol
Mouse Model
Calcified Cartilage
Chondrocyte
Subchondral Bone
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