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Journal / Biochemistry / Entschlüsselung der strukturellen Auswirkungen…
JoVE Journal
Biochemistry

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JoVE Journal Biochemistry
Entschlüsselung der strukturellen Auswirkungen der Aktivierung von EGFR-Somatischen Mutationen mit Molekulardynamik-Simulation
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Entschlüsselung der strukturellen Auswirkungen der Aktivierung von EGFR-Somatischen Mutationen mit Molekulardynamik-Simulation

Article DOI: 10.3791/61125-v • 15:05 min • May 20th, 2020
May 20th, 2020 •
1, 2, 2,3,4, 1
1Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 2Medicity Research Laboratories and Institute of Biomedicine, University of Turku, 3Turku Bioscience Centre, University of Turku and Åbo Akademi University, 4Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital

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Ziel dieses Protokolls ist es, mithilfe molekularer Dynamiksimulationen die dynamischen Strukturveränderungen zu untersuchen, die durch aktivierende Mutationen des EGFR-Kinaseproteins auftreten.

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In diesem Monat in JoVE Ausgabe 159 Molekulare Dynamiksimulationen Proteinstrukturanalysen Epidermal Wachstumsfaktor-Rezeptorfamilie Somatische Mutationen Krebs
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