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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
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Cancer Research
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JoVE Journal Cancer Research
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

English

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6,831 Views

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06:44 min

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June 07, 2020

DOI:

10.3791/61272-v

DOI:
10.3791/61272-v

•

06:44 min
June 07, 2020

•

23 Views
, , , , , ,
1The Comprehensive Cancer Center,The Ohio State University, 2Department of Radiation Oncology,The Ohio State University, 3Department of Veterinary Biosciences,The Ohio State University, 4Davis Heart & Lung Research Institute,The Ohio State University

Summary

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Intracranial brain metastasis modeling is complicated by an inability to monitor tumor size and response to treatment with precise and timely methods. The presented methodology couples intracranial tumor injection with magnetic resonance imaging analysis, which when combined, cultivates precise and consistent injections, enhanced animal monitoring, and accurate tumor volume measurements.

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Cite this Article

Geisler, J. A., Spehar, J. M., Steck, S. A., Bratasz, A., Shakya, R., Powell, K., Sizemore, G. M. Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging. J. Vis. Exp. (160), e61272, doi:10.3791/61272 (2020).

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