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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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JoVE Journal Cancer Research
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

DOI:
10.3791/59101-v

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05:19 min

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March 29, 2019

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, , ,
1Department of Surgery, Division of Urology,NorthShore University HealthSystem, 2Department of Radiology,Northwestern University Feinberg School of Medicine, 3Department of Urology,Northwestern University Feinberg School of Medicine

Chapters

  • 00:04Title
  • 00:29N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) Tumor Induction and Magnetic Resonance Imaging (MRI) Acquisition and Analysis
  • 02:56Bladder Dissection
  • 03:56Results: Representative MRI Assessment of BBN-Induced Murine Bladder Tumors
  • 04:43Conclusion

Summary

Automatic Translation

Automatic Translation

Murine bladder tumors are induced with the N-butyl-N-(4-hydroxybutyl) nitrosamine carcinogen (BBN). Bladder tumor generation is heterogeneous; therefore, an accurate assessment of tumor burden is needed before randomization to experimental treatment. Here we present a fast, reliable MRI protocol to assess tumor size and stage.

Tags

Keywords: Magnetic Resonance ImagingCarcinogen-inducedMurine Bladder TumorsBBNC57 Black Six MiceSubcutaneous InjectionRectal Temperature ProbeQuadrature Receiver CoilTrue Fast Imaging With Steady-state ProgressionAxialCoronalSagittal PlanesImage Analysis Software

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