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Journal / Immunology and Infection / Stabilitet og struktur Bat Major…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Stabilitet og struktur Bat Major Histocompatibility Complex Klasse I med heterolog β2-Microglobulin
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Stabilitet og struktur Bat Major Histocompatibility Complex Klasse I med heterolog β2-Microglobulin

Article DOI: 10.3791/61462-v • 11:17 min • March 10th, 2021
March 10th, 2021 •
*1,2, *3,4, *2,5, 1,2, 1,2, 2, 2, 4, 1, 4, 1,2
1School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, 2NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 3Faculty of Health Sciences, University of Macau, 4CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 5Savaid Medical School, University of Chinese Academy of Sciences
* These authors contributed equally

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Protokollen beskriver eksperimentelle metoder til at opnå stabile større histokompatibilitetskomplekser (MHC) klasse I gennempotentielleβ 2-mikroglobulin (β2m) substitutioner fra forskellige arter. Den strukturelle sammenligning af MHC I stabiliseret af homologe og heterologe β2m blev undersøgt.

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Immunologi og infektion Major histokompatibilitet antigen kompleks (MHC) klasse I molekyler β 2-mikroglobulin (β2m) kompleks struktur peptid TCR tetramer
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