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An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
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Bioengineering
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JoVE Journal Bioengineering
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

DOI:
10.3791/62133-v

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07:50 min

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June 04, 2021

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, ,
1Department of Radiology,University of Chicago, 2Graduate Program in Medical Physics,University of Chicago

Chapters

  • 00:05Introduction
  • 00:57Histotripsy Source and Imaging Array Setup
  • 01:54Clot Preparation and Flow Channel Priming
  • 03:35Pre-Treatment
  • 04:22Treatment
  • 05:22Post-Experimental Procedure
  • 05:51Results: Representative Clot Identification and Lysotripsy
  • 07:08Conclusion

Summary

Automatic Translation

Automatic Translation

Histotripsy-aided lytic delivery or lysotripsy is under development for the treatment of deep vein thrombosis. An in vitro procedure is presented here to assess the efficacy of this combination therapy. Key protocols for the clot model, image guidance, and assessment of treatment efficacy are discussed.

Tags

AI-assisted ThrombolysisHistotripsyLysotripsyIn Vitro Clot ModelDeep Vein ThrombosisBubble CloudUltrasound ImagingNon-invasive Treatment

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