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The Establishment and Utilization of Patient Derived Xenograft Models of Central Nervous System Metastasis
This content is Free Access.
Chapters
- 00:05Introduction
- 00:47Subcutaneous Flank Implantation of Patient Derived Xenograft (PDX) Tumor
- 01:48Orthotopic Implantation of PDX Tumor
- 04:24Intracardiac Implantation of PDX Tumor
- 05:47Results: Morphology and Metastasis of Implanted PDX Tumors
- 06:23Conclusion
Central nervous system metastasis PDX models represent the phenotypic and molecular characteristics of human metastasis, making them excellent models for preclinical studies. Described here is how to establish PDX models and the inoculation routes that are best used for preclinical studies.
