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Burn Injury-Induced Pain and Depression-Like Behavior in Mice
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JoVE Journal Neuroscience
Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

DOI:
10.3791/62817-v

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07:08 min

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September 29, 2021

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, , , , , ,
1Department of Physiology and Medical Science, College of Medicine and Brain Research Institute,Chungnam National University, 2Department of Pharmacology,Catholic Kwandong University College of Medicine

Chapters

  • 00:04Introduction
  • 00:44Induction of Scalding Burn Injury on the Hind Paw
  • 01:43Measurement of Mechanical Allodynia and Automated Gait Analysis
  • 03:49Measurement of Depression-Like Behavior and Normal Motor Function
  • 04:45Results: Mechanical Allodynia, Gait Analysis, and Depression-Like Behavior in Burn Injury-Induced Mice
  • 06:23Conclusion

Summary

Automatic Translation

Automatic Translation

A transient scald injury (65 °C ± 0.5 °C, 3 s) of one hind paw decreases the threshold (g) to von Frey filament stimulation of the ipsilateral side and alters gait pattern. Besides, burn injury induces depression-like behavior in the forced swimming test.

Tags

Keywords: Burn InjuryPainDepression-like BehaviorMouse ModelMechanical ThresholdGait AnalysisVon Frey FilamentsHot Water-induced Burn

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